Ribes G, Valette G, Lignon F, Loubatières-Mariani M M
C R Seances Soc Biol Fil. 1977;171(4):870-5.
In the anesthetized dog normal or pretreated with phenformin (20 mg/kg per os) for 7 days, a subcutaneous injection of this biguanide (20 mg/kg) triggers a considerable hyperinsulinemia without concomitant hypoglycemia. The insulin secreted by these animals is biologically active on rat epididymal fat pads. On the other hand, epididymal fat pads of rats pretreated with phenformin display a lower response to insulin than that of non treated rats. The hypoglycemic effect of the same dose of insulin is less important in the normal dog after chronic pretreatment with phenformin.
在麻醉犬中，正常犬或用苯乙双胍（20毫克/千克，口服）预处理7天的犬，皮下注射这种双胍类药物（20毫克/千克）会引发显著的高胰岛素血症，且无伴随的低血糖。这些动物分泌的胰岛素对大鼠附睾脂肪垫具有生物活性。另一方面，用苯乙双胍预处理的大鼠附睾脂肪垫对胰岛素的反应比未处理的大鼠低。在正常犬经苯乙双胍慢性预处理后，相同剂量胰岛素的降血糖作用减弱。
