Loubatières-Mariani M M, Alric R, Blayac J P, Valette G
Horm Metab Res. 1979 Feb;11(2):95-9. doi: 10.1055/s-0028-1092687.
Phenformin at high doses (10 mg/l, 50 mg/l, and 100 mg/l) increased the insulin and lactate output rates by the isolated perfused rat pancreas. Glucagon secretion was not modified. There was a statistically significant correlation between the increase in insulin and lactate output rates induced by phenformin. Intra-pancreatic L (+) lactate concentrations induced by phenformin were in the range of sodium L (+) lactate concentrations which experimentally stimulated insulin secretion by the same preparation. Thiamin pyrophosphate and sodium dichloroacetate, which promote the aerobic metabolism of pyruvate, opposed the phenoformin induced increase in lactate output by the isolated perfused rat pancreas and provoked as well a decrease in insulin release. These results suggest that the increase in insulin secretion following the administration of phenformin at high concentrations can be explained, to a large extent, by the increase in the production of lactate ions.
高剂量（10毫克/升、50毫克/升和100毫克/升）的苯乙双胍可增加离体灌注大鼠胰腺的胰岛素和乳酸输出率。胰高血糖素分泌未发生改变。苯乙双胍诱导的胰岛素和乳酸输出率增加之间存在统计学上的显著相关性。苯乙双胍诱导的胰腺内L（+）乳酸浓度处于实验性刺激同一制剂胰岛素分泌的L（+）乳酸钠浓度范围内。促进丙酮酸有氧代谢的硫胺素焦磷酸和二氯乙酸钠，可对抗苯乙双胍诱导的离体灌注大鼠胰腺乳酸输出增加，并导致胰岛素释放减少。这些结果表明，高浓度苯乙双胍给药后胰岛素分泌的增加在很大程度上可由乳酸离子产生的增加来解释。
