Angiotensin AT2 receptors: cardiovascular hope or hype?
作者信息
Widdop Robert E, Jones Emma S, Hannan Ruth E, Gaspari Tracey A
机构信息
Department of Pharmacology, Monash University, Melbourne, Victoria 3800, Australia.
出版信息
Br J Pharmacol. 2003 Nov;140(5):809-24. doi: 10.1038/sj.bjp.0705448. Epub 2003 Oct 6.
Abstract
摘要
相似文献
1
Angiotensin AT2 receptors: cardiovascular hope or hype?血管紧张素AT2受体：是心血管领域的希望还是炒作？
Br J Pharmacol. 2003 Nov;140(5):809-24. doi: 10.1038/sj.bjp.0705448. Epub 2003 Oct 6.
2
Hypovolaemia-induced vasodilatation during angiotensin AT1 receptor blockade: role of the AT2 receptor.
Pharmacol Res. 2005 Jan;51(1):37-40. doi: 10.1016/j.phrs.2004.07.010.
3
Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism.阿利吉仑通过缓激肽 B2 受体和血管紧张素 AT2 受体介导的机制减轻心肌缺血再灌注损伤。
Hypertension. 2014 Apr;63(4):768-73. doi: 10.1161/HYPERTENSIONAHA.113.02902. Epub 2014 Jan 13.
4
Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation.血管紧张素2型受体抑制肾素生物合成和血管紧张素II的形成。
Hypertension. 2005 Jan;45(1):133-7. doi: 10.1161/01.HYP.0000149105.75125.2a. Epub 2004 Nov 8.
5
Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries.血管紧张素II 2型受体介导的人冠状动脉微血管舒张
Circulation. 2004 May 18;109(19):2296-301. doi: 10.1161/01.CIR.0000128696.12245.57. Epub 2004 Apr 26.
6
Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors.内源性激肽介导的流量依赖性扩张需要血管紧张素AT2受体。
Circ Res. 2004 Jun 25;94(12):1623-9. doi: 10.1161/01.RES.0000131497.73744.1a. Epub 2004 May 6.
7
Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP.通过肾间质液中环鸟苷酸（cGMP）定量分析血管紧张素Ⅱ1型受体（AT1）阻滞剂缬沙坦和氯沙坦之间对血管紧张素Ⅱ2型受体（AT2）刺激的差异。
J Hypertens. 2002 Jun;20(6):1157-63. doi: 10.1097/00004872-200206000-00028.
8
Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase.血管紧张素II/AT2受体诱导的易中风自发性高血压大鼠血管舒张涉及一氧化氮和环鸟苷酸依赖性蛋白激酶。
J Hypertens. 2006 Dec;24(12):2417-22. doi: 10.1097/01.hjh.0000251902.85675.7e.
9
Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II.转化生长因子β受体内皮糖蛋白在心脏成纤维细胞中表达，并调节血管紧张素II的促纤维化作用。
Circ Res. 2004 Dec 10;95(12):1167-73. doi: 10.1161/01.RES.0000150369.68826.2f. Epub 2004 Nov 11.
10
Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice.在缓激肽B2受体缺失的小鼠中，血管紧张素AT2受体直接刺激肾脏一氧化氮的生成。
Hypertension. 2003 Oct;42(4):600-4. doi: 10.1161/01.HYP.0000090323.58122.5C. Epub 2003 Sep 2.
引用本文的文献
1
ATIP1 Is a Suppressor of Cardiac Hypertrophy and Modulates AT2-Dependent Signaling in Cardiac Myocytes.ATIP1是心肌肥厚的抑制因子，并调节心肌细胞中依赖于AT2的信号传导。
Cells. 2025 Apr 28;14(9):645. doi: 10.3390/cells14090645.
2
Microvascular angiotensin II type 2 receptor function is enhanced in young females and declines in a model of murine aging.微血管2型血管紧张素受体功能在年轻雌性中增强，而在小鼠衰老模型中则下降。
J Cardiovasc Aging. 2024 Jul;4(2). doi: 10.20517/jca.2024.09. Epub 2024 Aug 14.
3
Untangling the Uncertain Role of Overactivation of the Renin-Angiotensin-Aldosterone System with the Aging Process Based on Sodium Wasting Human Models.基于钠耗竭人类模型探讨肾素-血管紧张素-醛固酮系统过度激活与衰老过程的不确定作用。
Int J Mol Sci. 2024 Aug 28;25(17):9332. doi: 10.3390/ijms25179332.
4
Differential gene expression in the kidneys of SHR and WKY rats after intravenous administration of Akkermansia muciniphila-derived extracellular vesicles.静脉注射黏蛋白阿克曼氏菌衍生的细胞外囊泡后 SHR 和 WKY 大鼠肾脏中的差异基因表达。
Sci Rep. 2024 Aug 29;14(1):20056. doi: 10.1038/s41598-024-69757-x.
5
Unlocking the protective potential of the angiotensin type 2 receptor (ATR) in acute lung injury and age-related pulmonary dysfunction.揭示血管紧张素2型受体（ATR）在急性肺损伤和年龄相关性肺功能障碍中的保护潜力。
Biochem Pharmacol. 2024 Feb;220:115978. doi: 10.1016/j.bcp.2023.115978. Epub 2023 Dec 9.
6
Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer.血管紧张素 II 及其受体在胚胎着床期子宫内膜中的分布与反复胚胎移植失败患者的微血管密度及妊娠结局的关系。
Front Endocrinol (Lausanne). 2023 Aug 29;14:1206326. doi: 10.3389/fendo.2023.1206326. eCollection 2023.
7
Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes.揭示血管紧张素 II 和氯沙坦诱导的基因调控网络：用人尿液来源的足细胞进行研究。
Int J Mol Sci. 2023 Jun 23;24(13):10551. doi: 10.3390/ijms241310551.
8
Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity.槲皮素和坎地沙坦对多柔比星诱导的心脏毒性的改善作用评价。
Vasc Health Risk Manag. 2022 Dec 13;18:857-866. doi: 10.2147/VHRM.S381485. eCollection 2022.
9
The Angiotensin AT Receptor: From a Binding Site to a Novel Therapeutic Target.血管紧张素 AT 受体：从结合位点到新的治疗靶点。
Pharmacol Rev. 2022 Oct;74(4):1051-1135. doi: 10.1124/pharmrev.120.000281.
10
Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor.血管紧张素 II 型受体和缓激肽 B2 型受体异源二聚化后的新型药理学
Front Endocrinol (Lausanne). 2022 May 26;13:848816. doi: 10.3389/fendo.2022.848816. eCollection 2022.
本文引用的文献
1
AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR.在清醒的自发性高血压大鼠中，AT1受体阻断可揭示AT2受体介导的血管舒张作用。
Br J Pharmacol. 2004 Jul;142(5):821-30. doi: 10.1038/sj.bjp.0705838. Epub 2004 Jun 14.
2
Differential regulation by AT(1) and AT(2) receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta.血管紧张素II刺激大鼠子宫动脉和主动脉中环鸟苷酸生成时，AT(1)和AT(2)受体的差异调节
Br J Pharmacol. 2004 Mar;141(6):1024-31. doi: 10.1038/sj.bjp.0705694. Epub 2004 Mar 1.
3
Functional role of angiotensin II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide.血管紧张素II AT2受体在调节大鼠子宫动脉中AT1受体介导的收缩中的功能作用：缓激肽和一氧化氮的参与
Br J Pharmacol. 2003 Nov;140(5):987-95. doi: 10.1038/sj.bjp.0705484. Epub 2003 Oct 6.
4
Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits.麻醉兔肾皮质和髓质循环中AT2受体的不同作用。
Hypertension. 2003 Aug;42(2):200-5. doi: 10.1161/01.HYP.0000083341.64034.00. Epub 2003 Jul 7.
5
Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells.缓激肽和一氧化氮在PC12 W细胞中对AT2受体介导的分化的作用。
J Neurochem. 2003 May;85(3):759-67. doi: 10.1046/j.1471-4159.2003.01719.x.
6
Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats.血管紧张素AT2受体刺激对正常血压的Wistar Kyoto大鼠血管环磷酸鸟苷生成的影响。
Int J Biochem Cell Biol. 2003 Jun;35(6):963-72. doi: 10.1016/s1357-2725(02)00265-0.
7
Localization of AT(2) receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy.使用[125I]CGP42112对自发性高血压大鼠和Wistar Kyoto大鼠孤束核中AT(2)受体的定位：单侧结状神经节切除术后非血管紧张素II结合位点的上调
Brain Res. 2003 Apr 4;968(1):139-55. doi: 10.1016/s0006-8993(03)02231-5.
8
Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling.AT2受体在心肌梗死后左心室重构中的心脏保护作用。
Hypertension. 2003 Mar;41(3 Pt 2):814-8. doi: 10.1161/01.HYP.0000048340.53100.43. Epub 2002 Dec 23.
9
Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis.心脏血管紧张素II 2型受体激活激肽/一氧化氮系统并抑制纤维化。
Hypertension. 2003 Jan;41(1):99-107. doi: 10.1161/01.hyp.0000050101.90932.14.
10
Effect of AT2 receptor on expression of AT1 and TGF-beta receptors in VSMCs from SHR.AT2受体对自发性高血压大鼠血管平滑肌细胞中AT1及转化生长因子-β受体表达的影响。
Hypertension. 2002 Dec;40(6):853-8. doi: 10.1161/01.hyp.0000042096.17141.b1.
Zotero 插件