Brissenden J E, Costa M T, Roberts M H
Can Med Assoc J. 1977 Dec 17;117(12):1411-3.
This paper reports a large kinship with a familial (21;22) translocation occurring in both the balanced and the unbalanced states. Recurrence risks for the (21;22) translocation in the unbalanced state are high (14%) for the offspring of female carriers as compared with those for the offspring of male carriers (4%), but the offspring of male carriers appear to have a much higher risk (50%) of being balanced carriers than those of female carriers (30%).
本文报道了一个大家族，其中存在一种家族性的(21;22)易位，该易位以平衡态和不平衡态两种形式出现。与男性携带者的后代相比，不平衡态(21;22)易位在女性携带者后代中的复发风险较高(14%)，但男性携带者的后代成为平衡携带者的风险(50%)似乎比女性携带者的后代(30%)高得多。
