Badiaga Sékéné, Barrau Karine, Brouqui Philippe, Durant Jacques, Malvy Denis, Janbon François, Bonnet Eric, Bosseray Annick, Sotto Albert, Peyramont Dominique, Dydymski Serge, Cazorla Celine, Tolou Hervé, Durant Jean Paul, Delmont Jean
Service des Maladies Infectieuses et Tropicales, Hôpital Nord, Marseille, and Infectio-Sud formation et recherche, 18 avenue des Baumettes, Nice, France.
J Travel Med. 2003 Sep-Oct;10(5):286-9.
Dengue fever (DF) is a mosquito-transmitted acute disease caused by any of four dengue flavivirus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) which is becoming a major public health problem in intertropical areas.1 DF is increasingly observed in febrile travelers returning from tropical areas,2 especially those returning from the Caribbean islands and Southeast Asia, but it is rarely diagnosed in travelers returning from Africa.3-8 Diagnosis is often serologic, and in most cases is not confirmed; virus isolation remains exceptional. In a retrospective study of 44 cases of imported DF diagnosed in France, we found that the epidemiologic, clinical and diagnostic characteristics of these cases were similar to those reported in other previous published studies; diagnosis was carried out with serology, and no virus isolation was reported. To draw the attention of physicians from nonendemic areas to the possible occurrence of dengue infection in febrile travelers from all tropical countries, including those in Africa, and to reinforce recommendations required to establish diagnosis with certainty, we report herein a prospective study from 1998-1999 which we compiled with our previously published data.
登革热（DF）是一种由四种登革热黄病毒血清型（DEN-1、DEN-2、DEN-3和DEN-4）中的任何一种通过蚊子传播的急性疾病，它正成为热带地区的一个主要公共卫生问题。1在从热带地区返回的发热旅行者中越来越多地观察到登革热，2特别是那些从加勒比群岛和东南亚返回的旅行者，但在从非洲返回的旅行者中很少被诊断出来。3 - 8诊断通常是血清学诊断，且在大多数情况下未得到证实；病毒分离仍然很少见。在一项对法国确诊的44例输入性登革热病例的回顾性研究中，我们发现这些病例的流行病学、临床和诊断特征与之前其他已发表研究中报告的特征相似；诊断是通过血清学进行的，且未报告病毒分离情况。为了引起非流行地区医生对所有热带国家（包括非洲国家）发热旅行者中可能发生登革热感染的关注，并强化确定性诊断所需的建议，我们在此报告一项1998 - 1999年的前瞻性研究，该研究结合了我们之前发表的数据。
