Shiraki Katsuya, Sugimoto Kazushi, Yamanaka Yutaka, Yamaguchi Yumi, Saitou Yukiko, Ito Keiichi, Yamamoto Norihiko, Yamanaka Takenari, Fujikawa Katsuhiko, Murata Kazumoto, Nakano Takeshi
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan.
Int J Mol Med. 2003 Nov;12(5):705-8.
The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of apoptosis. Since suppression of apoptosis is fundamentally important for carcinogenesis and tumor growth, we investigated the expression and function of XIAP in human hepatocellular carcinomas (HCCs). XIAP was expressed constitutively in HCC cell lines. Fourteen out of 20 (70%) HCC tissues demonstrated moderate or strong cytoplasmic staining for XIAP, whereas non-tumor parts showed negative or weak staining for XIAP by immunohistochemistry. In addition, XIAP expression was inversely correlated with apoptosis, but not with proliferation in HCC tissues. These results indicated that XIAP is a principal inhibitor of apoptosis overexpressed in human HCCs and that XIAP may be a potential target for gene therapy of human HCCs.
X连锁凋亡抑制蛋白（XIAP）是凋亡抑制蛋白新家族的成员。由于凋亡抑制对于肿瘤发生和肿瘤生长至关重要，我们研究了XIAP在人类肝细胞癌（HCC）中的表达及功能。XIAP在肝癌细胞系中组成性表达。20例肝癌组织中有14例（70%）通过免疫组化显示XIAP呈中度或强细胞质染色，而肿瘤旁组织显示XIAP呈阴性或弱染色。此外，在肝癌组织中XIAP表达与凋亡呈负相关，但与增殖无关。这些结果表明，XIAP是人类肝癌中过表达的主要凋亡抑制因子，并且XIAP可能是人类肝癌基因治疗的潜在靶点。
