Chapman Jean A, Terr Abba I, Jacobs Robert L, Charlesworth Ernest N, Bardana Emil J
University of California Medical Center, San Francisco, California, USA. jachapmn@swbellnet
Ann Allergy Asthma Immunol. 2003 Sep;91(3):222-32. doi: 10.1016/S1081-1206(10)63522-3.
To review the available literature on the subject of fungi (molds) and their potential impact on health and to segregate information that has scientific validity from information that is yet unproved and controversial.
This review represents a synthesis of the available literature in this area with the authors' collective experience with many patients presenting with complaints of mold-related illness.
Pertinent scientific investigation on toxic mold issues and previously published reviews on this and related subjects that met the educational objectives were critically reviewed.
Indoor mold growth is variable, and its discovery in a building does not necessarily mean occupants have been exposed. Human response to fungal antigens may induce IgE or IgG antibodies that connote prior exposure but not necessarily a symptomatic state. Mold-related disease has been discussed in the framework of noncontroversial and controversial disorders.
When mold-related symptoms occur, they are likely the result of transient irritation, allergy, or infection. Building-related illness due to mycotoxicosis has never been proved in the medical literature. Prompt remediation of water-damaged material and infrastructure repair should be the primary response to fungal contamination in buildings.
回顾关于真菌（霉菌）及其对健康潜在影响的现有文献，并区分具有科学有效性的信息与未经证实且存在争议的信息。
本综述综合了该领域的现有文献以及作者对众多主诉与霉菌相关疾病患者的集体经验。
对符合教育目标的关于有毒霉菌问题的相关科学调查以及此前发表的关于此主题及相关主题的综述进行了严格审查。
室内霉菌生长情况各异，在建筑物中发现霉菌并不一定意味着居住者已接触到。人体对真菌抗原的反应可能会诱导产生IgE或IgG抗体，这表明之前曾接触过，但不一定处于有症状状态。已在无争议和有争议的病症框架内讨论了与霉菌相关的疾病。
当出现与霉菌相关的症状时，它们可能是短暂刺激、过敏或感染的结果。医学文献中从未证实过因霉菌毒素中毒导致的与建筑物相关的疾病。对水损材料进行及时修复以及对基础设施进行维修应是应对建筑物内真菌污染的主要措施。
