AlzaiemAlazhari University, College of Medical Laboratory Sciences, Department of Clinical Chemistry, Khartoum, Sudan.
Omdurman Islamic University, Faculty of Medicine and Health Sciences, Department of Biochemistry, Khartoum, Sudan.
Afr Health Sci. 2022 Sep;22(3):399-406. doi: 10.4314/ahs.v22i3.43.
Epidemiological observations suggest links between osteoporosis and the risk of acute cardiovascular events. Whether the two clinical conditions are linked by common pathogenic factors or atherosclerosis per se remains incompletely understood. The reduction of bone density and osteoporosis in postmenopausal women contributes to elevated lipid parameters and body mass index (BMI).
To investigate the relationship between serum lipid profile, BMI and osteoporosis in postmenopausal women.
A prospective analytical case control-study conducted in Khartoum north hospital at Khartoum city, capital of the Sudan from April 2017 to March 2018 after ethical approval obtained from the local Research Ethics Committee of Faculty of Medical Laboratories, Alzaeim Alazhary University on the committee meeting number (109) on Wednesday 15th February 2017. A written informed consent was obtained from all participants to participate in the study.Two hundred postmenopausal women were enrolled in the study. The age was studied in one hundred osteoporosis postmenopausal women as a case group and one hundred non-osteoporosis postmenopausal women as control group. The serum lipid profiles were estimated using spectrophotometers (Mandry) and BMI calculated using Quetelet index formula. The data were analysed using SPSS version 16.
The BMI, serum total cholesterol, triglyceride, HDL and LDL in case group respectively were (24.846±2.1647, 251.190±27.0135 mg/dl, 168.790 ±45.774 mg/dl, 50.620 ± 7.174 mg/dl, 166.868 ±28.978 mg/dl). While the BMI, serum total cholesterol, triglyceride, HDL and LDL in control group respectively were (25.378 ±3.8115, 187.990 ± 26.611 mg/dl, 139.360±20.290 mg/dl, 49.480 ±4.659 mg/dl, 111.667 ±28.0045 mg/dl). All serum lipid profiles significantly increased (p=0.000) in the case group compared to the control group, except serum HDL was insignificant different between the case and control group and also BMI was insignificant different between the case and control group. There was a positive Pearson's correlation between BMD and serum total cholesterol (r= 0.832, P<0.01), serum LDL (r = 0.782, P<0.01) and serum triglyceride (r = 0.72, P<0.01).
Osteoporotic postmenopausal women had a significant increase in serum lipid profile and BMI. Moreover, we found a positive link between women with cardiovascular diseases and stroke.
流行病学观察表明，骨质疏松症与急性心血管事件的风险之间存在关联。这两种临床病症是否存在共同的致病因素，或者动脉粥样硬化本身仍然不完全清楚。绝经后妇女的骨密度和骨质疏松症的减少会导致脂质参数和体重指数（BMI）升高。
研究绝经后妇女的血清脂质谱、BMI 和骨质疏松症之间的关系。
这是一项前瞻性分析病例对照研究，于 2017 年 4 月至 2018 年 3 月在苏丹首都喀土穆的北喀土穆医院进行，研究获得了当地医学实验室研究伦理委员会的伦理批准，委员会会议编号为 2017 年 2 月 15 日星期三的 109 号。所有参与者都获得了书面知情同意书，同意参与研究。研究纳入了 200 名绝经后妇女。年龄在 100 名骨质疏松症绝经后妇女中进行研究，作为病例组，100 名非骨质疏松症绝经后妇女作为对照组。使用分光光度计（曼德里）估计血清脂质谱，使用奎特利特指数公式计算 BMI。数据使用 SPSS 版本 16 进行分析。
病例组的 BMI、血清总胆固醇、甘油三酯、HDL 和 LDL 分别为（24.846±2.1647、251.190±27.0135mg/dl、168.790±45.774mg/dl、50.620±7.174mg/dl、166.868±28.978mg/dl）。而对照组的 BMI、血清总胆固醇、甘油三酯、HDL 和 LDL 分别为（25.378±3.8115、187.990±26.611mg/dl、139.360±20.290mg/dl、49.480±4.659mg/dl、111.667±28.0045mg/dl）。与对照组相比，病例组的所有血清脂质谱均显著升高（p=0.000），除血清 HDL 组间差异无统计学意义，且病例组和对照组的 BMI 组间差异无统计学意义。BMD 与血清总胆固醇（r=0.832，P<0.01）、血清 LDL（r=0.782，P<0.01）和血清甘油三酯（r=0.72，P<0.01）之间存在正皮尔逊相关。
骨质疏松症绝经后妇女的血清脂质谱和 BMI 显著升高。此外，我们发现心血管疾病和中风患者之间存在正相关。
