微藻生物质和代谢产物的回收：工艺选择与经济性
Recovery of microalgal biomass and metabolites: process options and economics.
作者信息
Molina Grima E, Belarbi E-H, Acién Fernández F G, Robles Medina A, Chisti Yusuf
机构信息
Department of Chemical Engineering, University of Almería, E-04071 Almería, Spain.
出版信息
Biotechnol Adv. 2003 Jan;20(7-8):491-515. doi: 10.1016/s0734-9750(02)00050-2.
Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.
细胞内微藻代谢产物的商业化生产需要以下条件
(1) 大规模纯种培养合适的微藻生物质；(2) 从相对稀释的培养液中回收生物质；(3) 从生物质中提取代谢产物；(4) 粗提物的纯化。本综述探讨了从生物质中回收生物质和细胞内代谢产物的可用方法。以二十碳五烯酸（EPA）回收作为典型案例研究，讨论了在光生物反应器中微藻纯种生产以及下游代谢产物回收的经济性。
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