Horm Srey Viseth, Dumas Céline, Svay Sarath, Feldon Keith, Reynes Jean-Marc
Institut Pasteur du Cambodge, 5 Monivong Boulevard, BP 983, Phnom Penh, Cambodia.
Virus Res. 2003 Nov;97(1):31-7. doi: 10.1016/s0168-1702(03)00219-3.
Cambodian authorities in collaboration with the World Health Organization (WHO) are implementing a measles control plan in this measles endemic country. Genetic characterization of Cambodian wild-type measles viruses was performed to determine the genotypes involved in outbreaks, and to measure the level of virus circulation in a geographic area just beginning to implement the measles control program. Seventy-two sequences of the C terminus of the nucleoprotein gene of measles virus were obtained from 88 patients. Samples were taken from 35 among 519 outbreaks reported to the Cambodian National Immunization Program between March 2001 and June 2002. The sequences were grouped into 10 lineages which all belonged to genotype D5. The maximum nucleotide divergence was 1.3%.
柬埔寨当局与世界卫生组织（WHO）合作，正在这个麻疹流行国家实施一项麻疹控制计划。对柬埔寨野生型麻疹病毒进行了基因特征分析，以确定与疫情相关的基因型，并衡量在一个刚刚开始实施麻疹控制计划的地理区域内病毒的传播水平。从88名患者中获得了72条麻疹病毒核蛋白基因C末端的序列。样本取自2001年3月至2002年6月期间向柬埔寨国家免疫计划报告的519起疫情中的35起。这些序列被分为10个谱系，均属于D5基因型。最大核苷酸差异为1.3%。
