Zhang Yan, Ji Yixin, Jiang Xiaohong, Xu Songtao, Zhu Zhen, Zheng Lei, He Jilan, Ling Hua, Wang Yan, Liu Yang, Du Wen, Yang Xuelei, Mao Naiying, Xu Wenbo
WHO WPRO Regional Reference Measles Lab, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, PR China.
Virol J. 2008 Oct 20;5:120. doi: 10.1186/1743-422X-5-120.
Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.
利用N蛋白基因C端区域的核苷酸测序和对2004年来自中国16个省份的59株分离株的系统发育分析，对野生型麻疹病毒进行了基因特征研究。结果表明，所有分离株均属于H1基因型。51株属于第1簇，8株属于第2簇，两个簇的病毒在中国各地均有分布，无明显地理分布模式。59株H1毒株的核苷酸序列和预测的氨基酸同源性分别为96.5%-100%和95.7%-100%。该报告表明，2004年中国H1基因型病毒的传播模式与单一流行基因型多个谱系的持续地方性传播一致。多种传播途径导致了流行基因型内的多个谱系。
