Zhang Yan, Zhu Zhen, Rota Paul A, Jiang Xiaohong, Hu Jiayu, Wang Jianguo, Tang Wei, Zhang Zhenying, Li Congyong, Wang Changyin, Wang Tongzhan, Zheng Lei, Tian Hong, Ling Hua, Zhao Chunfang, Ma Yan, Lin Chunyan, He Jilan, Tian Jiang, Ma Yan, Li Ping, Guan Ronghui, He Weikuan, Zhou Jianhui, Liu Guiyan, Zhang Hong, Yan Xinge, Yang Xuelei, Zhang Jinlin, Lu Yiyu, Zhou Shunde, Ba Zhuoma, Liu Wei, Yang Xiuhui, Ma Yujie, Liang Yong, Li Yeqiang, Ji Yixin, Featherstone David, Bellini William J, Xu Songtao, Liang Guodong, Xu Wenbo
WHO Regional Reference Laboratory for Measles for the Western Pacific Region, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing 100050, China.
Virol J. 2007 Feb 5;4:14. doi: 10.1186/1743-422X-4-14.
This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%-100% and 93.3%-100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China.
本报告描述了1995年至2003年间在中国24个省份分离出的297株野生型麻疹病毒的基因特征。对N基因序列的系统发育分析表明，除3株为A基因型外，所有分离株均属于H1基因型。294株H1基因型毒株的核苷酸序列和预测的氨基酸同源性分别为94.7%-100%和93.3%-100%。H1基因型分离株分为2个簇，在核苷酸水平上相差约2.9%。来自两个簇的病毒在中国各地均有分布，没有明显的地理限制，许多省份存在多个共同流行的谱系。尽管在中国周边国家已检测到其他麻疹基因型，但本报告表明H1基因型在中国广泛分布，且中国有一种单一的地方性基因型。这些重要的基线数据将有助于监测中国麻疹控制工作的进展。
