Makolkin V I, Bazhanov N N, Petukhova N V, Men'shikova I V
Ter Arkh. 1992;64(5):53-4.
Patients suffering from active rheumatoid arthritis (RA) were examined for the analgesic effect of tramal. All the patients were administered basic therapy and nonsteroidal anti-inflammatory drugs. Tramal produced a beneficial effect in 79% of the patients. The stable analgesic effect ensued on days 3-5 since the onset of continuous treatment. Provided the drug was administered for a short period of time (not more than 14 days), addiction to tramal was not recorded. Only 11% of the patients demonstrated tramal-induced side effects (drowsiness, dizziness, skin itch), seen in cases where the daily dose exceeded 300 mg.
对患有活动性类风湿性关节炎(RA)的患者进行了曲马多镇痛效果的检查。所有患者均接受基础治疗和非甾体抗炎药治疗。曲马多对79%的患者产生了有益效果。自持续治疗开始后的第3至5天出现稳定的镇痛效果。如果药物使用时间较短(不超过14天),未记录到对曲马多的成瘾情况。仅11%的患者出现了曲马多引起的副作用(嗜睡、头晕、皮肤瘙痒),这些副作用出现在每日剂量超过300毫克的情况下。