Leonard F C, Quinn P J, Ellis W A, O'Farrell K
Moorepark Research and Development Centre, Fermoy, County Cork.
Vet Rec. 1992 Nov 7;131(19):435-9. doi: 10.1136/vr.131.19.435.
The excretion of Leptospira interrogans serovar hardjo in the urine of cattle was studied in naturally and experimentally infected animals. Five of 15 naturally infected animals with microscopic agglutination test titres of > or = 1:300 shed leptospires for between 28 and 40 weeks. Twenty yearling heifers, experimentally infected by either the supraconjunctival or intrauterine routes, shed leptospires for from eight to 60 weeks; the 10 infected via the uterus shed L interrogans serovar hardjo for a mean of 26 weeks (range eight to 54 weeks) and the 10 infected by the supraconjunctival route shed the organism for a mean of 32 weeks (range 12 to 60 weeks). The results suggest that natural infection results in more prolonged excretion than experimental infection. No intermittent or seasonal excretion of the organism was observed. After the initial experimental infection, large numbers of leptospires were shed in the urine for several weeks, and thereafter there was a progressive decline in the number of organisms shed.
在自然感染和实验感染的动物中，对牛尿液中问号钩端螺旋体哈焦血清型的排泄情况进行了研究。15只自然感染且显微镜凝集试验效价≥1:300的动物中，有5只排出钩端螺旋体的时间为28至40周。20头一岁小母牛通过结膜上或子宫内途径进行实验感染，排出钩端螺旋体的时间为8至60周；经子宫感染的10头牛排出问号钩端螺旋体哈焦血清型的平均时间为26周（范围为8至54周），经结膜上途径感染的10头牛排出该病原体的平均时间为32周（范围为12至60周）。结果表明，自然感染导致的病原体排泄时间比实验感染更长。未观察到该病原体的间歇性或季节性排泄。在初次实验感染后，尿液中会在数周内排出大量钩端螺旋体，此后排出的病原体数量逐渐下降。
