• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

特发性脊柱侧凸的病因及发病机制。

The etiology and pathogenesis of idiopathic scoliosis.

作者信息

Dickson R A

机构信息

University Department of Orthopaedic Surgery, St James's University Hospital, Leeds, United Kingdom.

出版信息

Acta Orthop Belg. 1992;58 Suppl 1:21-5.

PMID:1456009
Abstract

Idiopathic scoliosis is a complex three-dimensional deformity and in the thoracic region the essential lesion lies in the sagittal plane in the form of an area of inappropriate lordosis. The thoracic kyphosis is normally protected from buckling by being behind the axis of spinal column rotation but when the thoracic lordosis develops it brings the apical region anterior to this axis and thus under compression with resultant buckling failure of the spinal column. The condition of idiopathic thoracic scoliosis is the opposite to idiopathic hyperkyphosis (Scheuermann's disease), the latter being rotationally stable and not moving out of the sagittal plane. The two frequently co-exist in the same spine with thoracic hyperkyphosis above an area of lumbar lordo-scoliosis. There is a spectrum of normal lateral profile and flat backs at the one end are in danger of buckling (lordo-scoliosis) while round backs at the other end of the spectrum are in danger of being defined as Scheuermann's disease. There is no requirement for a specific pathological process. Engineers describe only two ways in which a flexible column can fall into mechanically-angular collapse (kyphosis) and column buckling (lordo-scoliosis). A number of factors favour column buckling (Euler's law) and thus the bigger a deformity the more likely it will be to continue progressing and the taller and more slender the column the more likely it will be to fail and this we see in our patients with idiopathic scoliosis. Not only is lordosis the essential lesion but it is also the primary abnormality which can be demonstrated in children before lateral curvature and rotation develop.

摘要

特发性脊柱侧凸是一种复杂的三维畸形,在胸段,主要病变位于矢状面,表现为不当前凸区域的形式。胸椎后凸通常通过位于脊柱旋转轴后方而免受屈曲影响,但当胸椎前凸发展时,它会使顶点区域位于该轴前方,从而受到压缩,导致脊柱屈曲失败。特发性胸段脊柱侧凸的情况与特发性脊柱后凸(休曼病)相反,后者在旋转方面稳定,不会移出矢状面。这两种情况经常在同一脊柱中共存,胸段脊柱后凸位于腰段脊柱侧凸区域上方。正常侧位轮廓存在一个范围,一端的平背有屈曲(脊柱侧凸)的风险,而另一端的圆背有被定义为休曼病的风险。不需要特定的病理过程。工程师们描述了柔性柱陷入机械角塌陷(脊柱后凸)和柱屈曲(脊柱侧凸)的仅两种方式。一些因素有利于柱屈曲(欧拉定律),因此畸形越大,它继续进展的可能性就越大,柱越高越细长,它失败的可能性就越大,这在我们的特发性脊柱侧凸患者中可以看到。不仅前凸是主要病变,而且它也是在儿童出现侧弯和旋转之前就可以表现出来的主要异常。

相似文献

1
The etiology and pathogenesis of idiopathic scoliosis.特发性脊柱侧凸的病因及发病机制。
Acta Orthop Belg. 1992;58 Suppl 1:21-5.
2
Idiopathic scoliosis: biomechanics and biology.特发性脊柱侧弯:生物力学与生物学
Eur Spine J. 1996;5(6):362-73. doi: 10.1007/BF00301963.
3
The aetiology of spinal deformities.脊柱畸形的病因学。
Lancet. 1988 May 21;1(8595):1151-5. doi: 10.1016/s0140-6736(88)91963-0.
4
Idiopathic scoliosis: foundation for physiological treatment.特发性脊柱侧凸:生理治疗基础
Ann R Coll Surg Engl. 1987 May;69(3):89-96.
5
The experimental basis of idiopathic scoliosis.特发性脊柱侧凸的实验基础。
Clin Orthop Relat Res. 1986 Sep(210):9-17.
6
The anatomy of spinal deformity: a biomechanical analysis.
Orthopedics. 1987 Jun;10(6):897-903. doi: 10.3928/0147-7447-19870601-09.
7
Combined idiopathic kyphosis and scoliosis. An analysis of the lateral spinal curvatures associated with Scheuermann's disease.特发性脊柱后凸和脊柱侧凸合并症。与休曼氏病相关的脊柱侧方弯曲分析。
J Bone Joint Surg Br. 1985 Mar;67(2):189-92. doi: 10.1302/0301-620X.67B2.3980523.
8
[Idiopathic scoliosis in the sagittal plane].
Beitr Orthop Traumatol. 1989 Oct-Nov;36(10-11):520-9.
9
[The sagittal curvature of spine in idiopathic scoliosis--its morphological features and the correlation among sagittal and frontal curvatures and rotation of apical vertebra].[特发性脊柱侧凸中脊柱矢状面弯曲——其形态学特征以及矢状面与额状面弯曲及顶椎旋转之间的相关性]
Nihon Seikeigeka Gakkai Zasshi. 1985 May;59(5):505-16.
10
Three-dimensional spinal curvature in idiopathic scoliosis.特发性脊柱侧凸中的三维脊柱弯曲度
J Orthop Res. 1987;5(1):102-13. doi: 10.1002/jor.1100050113.

引用本文的文献

1
Loss of Tyrosine Phosphatase Mu Promotes Scoliosis Progression Through Osteopontin-α5β1 Integrin Signaling and PIPK1γ90 Activity.酪氨酸磷酸酶 Mu 的缺失通过骨桥蛋白-α5β1 整合素信号通路和磷脂酰肌醇磷酸激酶 1γ90 活性促进脊柱侧弯进展。
Int J Mol Sci. 2025 Jan 26;26(3):1042. doi: 10.3390/ijms26031042.
2
The orthopedic characterization of cfap298 mutants validate zebrafish to faithfully model human AIS.cfap298 突变体的骨骼特征验证了斑马鱼能够真实地模拟人类 AIS。
Sci Rep. 2021 Apr 1;11(1):7392. doi: 10.1038/s41598-021-86856-1.
3
Quantitative imaging of the spine in adolescent idiopathic scoliosis: shifting the paradigm from diagnostic to comprehensive prognostic evaluation.
青少年特发性脊柱侧凸的脊柱定量成像:从诊断范式转向全面预后评估。
Eur J Orthop Surg Traumatol. 2021 Oct;31(7):1273-1285. doi: 10.1007/s00590-021-02883-8. Epub 2021 Jan 31.
4
True 3D parameters of the spinal deformity in adolescent idiopathic scoliosis.青少年特发性脊柱侧凸中脊柱畸形的真实 3D 参数。
Spine Deform. 2021 May;9(3):703-710. doi: 10.1007/s43390-020-00254-7. Epub 2021 Jan 5.
5
3D Deformation Patterns of S Shaped Elastic Rods as a Pathogenesis Model for Spinal Deformity in Adolescent Idiopathic Scoliosis.S 形弹性杆的三维变形模式作为青少年特发性脊柱侧凸脊柱畸形的发病机制模型。
Sci Rep. 2019 Nov 11;9(1):16485. doi: 10.1038/s41598-019-53068-7.
6
Classifications in Brief: The Lenke Classification for Adolescent Idiopathic Scoliosis.简要分类:青少年特发性脊柱侧凸的Lenke分类
Clin Orthop Relat Res. 2018 Nov;476(11):2271-2276. doi: 10.1097/CORR.0000000000000405.
7
Maternal Diets Deficient in Vitamin D Increase the Risk of Kyphosis in Offspring: A Novel Kyphotic Porcine Model.母体维生素 D 缺乏饮食会增加后代脊柱后凸的风险:一种新型的脊柱后凸猪模型。
J Bone Joint Surg Am. 2018 Mar 7;100(5):406-415. doi: 10.2106/JBJS.17.00182.
8
The impact of direct vertebral rotation (DVR) on radiographic outcome in surgical correction of idiopathic scoliosis.直接椎体旋转(DVR)对特发性脊柱侧弯手术矫正中影像学结果的影响。
Arch Orthop Trauma Surg. 2017 Jul;137(7):879-885. doi: 10.1007/s00402-017-2700-4. Epub 2017 Apr 24.
9
Thoracic sagittal plane variations between patients with thoracic adolescent idiopathic scoliosis and healthy adolescents.青少年特发性胸椎侧弯患者与健康青少年之间的胸椎矢状面差异。
Eur Spine J. 2016 Oct;25(10):3095-3103. doi: 10.1007/s00586-016-4400-0. Epub 2016 Jan 28.
10
Magnetic resonance imaging investigations of position of conus medullaris in adolescent idiopathic scoliosis as a peripheral neuropathy.青少年特发性脊柱侧凸中圆锥马尾位置的磁共振成像研究作为一种周围神经病变。
Int J Clin Exp Med. 2015 Apr 15;8(4):5918-24. eCollection 2015.