Peng X Q, Ke J
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1992 Jul;13(4):357-8.
After 30-min ischemia and 60-min reperfusions in rats by ligating bilateral vertebral and common carotid arteries, the brain calcium contents were increased from 171 +/- 6 micrograms in control group to 192 +/- 10 micrograms with abnormal EEG activities and ischemic injury in the brain tissues. Anisodamine 6.67 mg.kg-1, scopolamine 0.67 mg.kg-1 or atropine 0.67 mg.kg-1 injected ip decreased the elevated calcium contents of the rat brain to the level of control, reduced the ischemic injury of brain tissue, and promoted the recovery of EEG activities. The findings showed that the 3 henbane drugs might prevent the brain tissues from ischemic damage through reducing intracellular Ca2+ accumulation resulted from ischemia and reperfusion event.
通过结扎大鼠双侧椎动脉和颈总动脉造成30分钟缺血及60分钟再灌注后，脑组织钙含量从对照组的171±6微克增加至192±10微克，伴有脑电图活动异常及脑组织缺血损伤。腹腔注射6.67毫克·千克-1山莨菪碱、0.67毫克·千克-1东莨菪碱或0.67毫克·千克-1阿托品可使大鼠脑内升高的钙含量降至对照水平，减轻脑组织缺血损伤，并促进脑电图活动恢复。研究结果表明，这三种莨菪类药物可能通过减少缺血再灌注所致细胞内Ca2+蓄积来防止脑组织缺血损伤。
