Peng X, Coa S, Ke J
Department of Pharmacology, Henan Medical University, Zhengzhou.
Chin Med Sci J. 1995 Dec;10(4):237-9.
In order to investigate the mechanisms of acute cerebral ischemia, and to look for effective drugs on cerebral resuscitation, we made a model of acute complete global brain ischemia, reperfusion and resuscitation on rats according to Garavilla's method. Our results showed that the event of cerebral ischemia and reperfusion injury could result in the increase of total brain calcium content, and anisodamine has the same reducing brain calcium contents as diltiazem's, while improving neurological outcome and alleviating injury to neurons.
为了探讨急性脑缺血的机制，并寻找有效的脑复苏药物，我们按照加拉维拉的方法制作了大鼠急性完全性全脑缺血、再灌注及复苏模型。我们的结果表明，脑缺血及再灌注损伤事件可导致全脑钙含量增加，山莨菪碱与地尔硫䓬一样具有降低脑钙含量的作用，同时可改善神经功能转归并减轻神经元损伤。
