目标：最初的10年。

TOR: the first 10 years.

作者信息

Lorberg A, Hall M N

机构信息

Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstr. 70, 4056, Basel, Switzerland.

出版信息

Curr Top Microbiol Immunol. 2004;279:1-18. doi: 10.1007/978-3-642-18930-2_1.

DOI:10.1007/978-3-642-18930-2_1

PMID:14560948

Abstract

TOR was discovered and christened 10 years ago. On the occasion of this anniversary, we revisit the discovery of TOR and chronicle subsequent breakthroughs in S. cerevisiae that contributed to an understanding of TOR function in yeast and higher eukaryotes. In particular, we discuss findings that led to the realization that the function of TOR is to control cell growth in response to nutrients.

摘要

TOR于10年前被发现并命名。在这个周年之际，我们回顾TOR的发现，并记录酿酒酵母中随后的突破，这些突破有助于理解TOR在酵母和高等真核生物中的功能。特别是，我们讨论了那些使人们认识到TOR的功能是响应营养物质来控制细胞生长的研究结果。