注入人体的胆固醇通过一种3-酮中间体转化为胆甾烷醇。
Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate.
作者信息
Rosenfeld R S, Zumoff B, Hellman L
机构信息
Institute for Steroid Research and the Division of Neoplastic Medicine, Montefiore Hospital and Medical Center, New York, USA.
出版信息
J Lipid Res. 1967 Jan;8(1):16-23.
Cholesterol-3-(3)H,4-(14)C was injected intravenously in man and its transformation to cholestanol was studied. From the (3)H: (14)C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-(3)H,4-(14)C the (3)H: (14)C ratios in blood sterols remained unchanged for as long as 1 wk after the injection, which showed that cholestanol did not lose tritium by interconversion with cholestanone.
将胆固醇 -3-(³H)，4-(¹⁴C)静脉注射入人体，并研究其向胆甾烷醇的转化。从血液中分离出的胆甾烷醇的³H:¹⁴C比值，获得了酮中间体参与该转化的证据。在另一名接受胆甾烷醇 -3-(³H)，4-(¹⁴C)的受试者中，注射后长达1周，血液中甾醇的³H:¹⁴C比值保持不变，这表明胆甾烷醇不会通过与胆甾烷酮的相互转化而失去氚。
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