Chan-Yeung M, Desjardins A
Department of Medicine, University of British Columbia, Vancouver, Canada.
Am Rev Respir Dis. 1992 Dec;146(6):1606-9. doi: 10.1164/ajrccm/146.6.1606.
Four workers from a cedar sawmill who developed red cedar asthma are described. They had serial measurements of lung function and nonspecific bronchial hyperresponsiveness (NSBH) several years before and after the development of chest symptoms. Measurements of dust concentration and specific IgE antibodies to plicatic acid-human serum albumin (PA-HSA) conjugate were also carried out before the onset of disease. NSBH developed in parallel with the development of asthma and was not present in any of the workers beforehand, indicating that it is not a predisposing host factor. Nasal symptoms preceded chest symptoms in three workers, suggesting that this may be an early marker of the disease. Although dust concentrations for jobs located both inside and outside the sawmill were low, jobs associated with somewhat higher exposures were associated with the initiation of asthma symptoms.
本文描述了四名来自雪松锯木厂并患上红雪松哮喘的工人。在出现胸部症状的几年前后，他们接受了肺功能和非特异性支气管高反应性（NSBH）的系列测量。在疾病发作前，还进行了粉尘浓度测量以及针对扁柏酸 - 人血清白蛋白（PA - HSA）共轭物的特异性IgE抗体检测。NSBH与哮喘的发展同步出现，且在任何一名工人之前均不存在，这表明它不是一个预先存在的宿主因素。三名工人的鼻部症状先于胸部症状出现，这表明这可能是该疾病的一个早期标志。尽管锯木厂内外工作岗位的粉尘浓度都很低，但与接触量稍高相关的工作与哮喘症状的起始有关。
