Yokoyama Hisayo, Shoji Tetsuo, Kimoto Eiji, Shinohara Kayo, Tanaka Shinji, Koyama Hidenori, Emoto Masanori, Nishizawa Yoshiki
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
J Atheroscler Thromb. 2003;10(4):253-8. doi: 10.5551/jat.10.253.
Patients with type 2 diabetes mellitus are at an increased risk of atherosclerosis including peripheral arterial disease (PAD). The purpose of this study was to examine the possible alteration in pulse wave velocity (PWV) in lower-limb arteries among diabetic patients with PAD.
We measured brachial-ankle PWV (baPWV) using an automatic device in 101 healthy control subjects and 102 type 2 diabetic patients including those with PAD.
Diabetic patients without PAD showed a higher baPWV than the healthy control subjects. There was no significant difference in baPWV between the right and left legs in these groups. In contrast, among diabetic patients with PAD, baPWV was significantly lower in the affected legs than in the non-affected legs, and the reduction in baPWV was greater in those with lower ankle-brachial pressure index (ABI). In the patients with PAD who received percutaneous transluminal angioplasty, both baPWV and ABI were increased following successful vessel dilatation.
These results suggest that baPWV is increased in diabetic patients, whereas it is decreased in the affected legs in diabetic patients with PAD. Widening of the right-left difference in baPWV may be a novel marker of PAD.
2型糖尿病患者发生动脉粥样硬化（包括外周动脉疾病，PAD）的风险增加。本研究旨在探讨患有PAD的糖尿病患者下肢动脉脉搏波速度（PWV）的可能变化。
我们使用自动设备测量了101名健康对照者和102名2型糖尿病患者（包括患有PAD的患者）的臂踝PWV（baPWV）。
无PAD的糖尿病患者的baPWV高于健康对照者。这些组中左右腿的baPWV无显著差异。相比之下，在患有PAD的糖尿病患者中，患侧腿的baPWV明显低于未患侧腿，且踝肱压力指数（ABI）较低的患者baPWV降低幅度更大。在接受经皮腔内血管成形术的PAD患者中，血管成功扩张后baPWV和ABI均升高。
这些结果表明，糖尿病患者的baPWV升高，而患有PAD的糖尿病患者患侧腿的baPWV降低。baPWV左右差异的扩大可能是PAD的一个新标志物。
