Moolgavkar Suresh H, Luebeck E Georg
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Genes Chromosomes Cancer. 2003 Dec;38(4):302-6. doi: 10.1002/gcc.10264.
We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Environmental agents that increase the rate of clonal expansion of partially altered cells are efficient carcinogens. As a corollary, intervention strategies that decrease this rate are to be preferred to strategies that decrease the rate of early mutational events in carcinogenesis.
我们考虑多阶段致癌作用对人群中癌症发病率的影响。当正确考虑部分改变细胞的克隆扩增时，我们发现没有必要将基因组不稳定作为恶性转化的早期事件。增加部分改变细胞克隆扩增速率的环境因素是有效的致癌物。作为一个推论，降低这种速率的干预策略比降低致癌过程中早期突变事件速率的策略更可取。
