Claudy A
Service de dermatologie, hôpital Edouard-Herriot, pavillon R, 69437 Lyon, France.
Pathol Biol (Paris). 2003 Jul;51(5):260-3. doi: 10.1016/s0369-8114(03)00067-1.
The primary function of the epidermis is to produce the waterimpermeable stratum corneum that permits terrestrial life. Extracellular glycosylceramides are the main precursors of the stratum corneum ceramides which play a role in the cohesion of corneocytes and the establishment of the barrier function. The physiological desquamative process depends upon the transformation of glycosylceramides to ceramides and of cholesterol sulfate to cholesterol. Intracellular ceramides participate to the terminal differentiation process of the epidermis. Abnormalities in the synthesis and/or the secretory mechanisms of the epidermal lipids induce various skin disorders. Such diseases may have a genetic background or result from the influence of environmental factors.
表皮的主要功能是产生不透水的角质层，从而使陆地生物生存成为可能。细胞外糖基神经酰胺是角质层神经酰胺的主要前体，其对角质形成细胞的黏附以及屏障功能的建立发挥作用。生理性脱屑过程依赖于糖基神经酰胺向神经酰胺的转化以及硫酸胆固醇向胆固醇的转化。细胞内神经酰胺参与表皮的终末分化过程。表皮脂质合成和/或分泌机制的异常会引发各种皮肤疾病。这些疾病可能具有遗传背景，或者是环境因素影响所致。
