Braun Hans A, Voigt Karlheinz, Huber Martin T
Laboratory of Neurodynamics, Institute of Physiology, University of Marburg, Deutschhausstr. 2, D-35037 Marburg, Germany.
Biosystems. 2003 Sep;71(1-2):39-50. doi: 10.1016/s0303-2647(03)00108-4.
Modulation of neuronal impulse pattern is examined by means of a simplified Hodgkin-Huxley type computer model which refers to experimental recordings of cold receptor discharges. This model essentially consists of two potentially oscillating subsystems: a spike generator and a subthreshold oscillator. With addition of noise the model successfully mimics the major types of experimentally recorded impulse patterns and thereby elucidate different resonance behaviors. (1) There is a range of rhythmic spiking or bursting where the spike generator is strongly coupled to the subthreshold oscillator. (2) There is a pacemaker activity of more complex interactions where the spike generator has overtaken part of the control. (3) There is a situation where the two subsystems are decoupled and only resonate with the help of noise.
通过一个简化的霍奇金-赫胥黎型计算机模型来研究神经元冲动模式的调制，该模型参考了冷感受器放电的实验记录。这个模型主要由两个潜在振荡子系统组成：一个尖峰发生器和一个阈下振荡器。加入噪声后，该模型成功模拟了实验记录的主要冲动模式类型，从而阐明了不同的共振行为。（1）存在一系列节律性尖峰或爆发，此时尖峰发生器与阈下振荡器强烈耦合。（2）存在一种更复杂相互作用的起搏器活动，此时尖峰发生器已接管部分控制。（3）存在一种情况，即两个子系统解耦，仅在噪声的帮助下共振。
