Guzmán Manuel
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.
Nat Rev Cancer. 2003 Oct;3(10):745-55. doi: 10.1038/nrc1188.
Cannabinoids - the active components of Cannabis sativa and their derivatives - exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?
大麻素——大麻及其衍生物的活性成分——通过预防恶心、呕吐和疼痛以及刺激食欲，对癌症患者发挥缓解作用。此外，这些化合物已被证明在细胞培养和动物模型中通过调节关键细胞信号通路来抑制肿瘤细胞的生长。大麻素通常耐受性良好，不会产生传统化疗的全身性毒性作用。那么，大麻素能否用于开发新的抗癌疗法呢？
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