[Celastrol in the inhibition of neovascularization].
作者信息
Huang Yu-lun, Zhou You-xin, Zhou Dai, Xu Qi-nian, Ye Ming, Sun Cheng-fa, Du Zi-wei
机构信息
Department of Neurosurgery, First Hospital, Soochow University, Suzhou 215006, China.
出版信息
Zhonghua Zhong Liu Za Zhi. 2003 Sep;25(5):429-32.
OBJECTIVE
To study the inhibition effect of celastrol on neovascularization.
METHODS
The effect of celastrol on the in vitro proliferation of endothelial cell of vessel (ECV) was examined by MTT assay. The effect of celastrol on endothelial cell migration, tube formation on Matrigel and Chick chorioallantoic membrane angiogenesis was also examined. Matrigel plug assay was used to evaluate the effect of celastrol on angiogenesis in vivo.
RESULTS
The proliferation of ECV was inhibited significantly by celastrol with IC(50) being 1.33 microg/ml. Celastrol inhibited endothelial cell migration and tube formation in a dose-dependent manner. Celastrol also inhibited angiogenesis both in Matrigel plug of mouse model and in chick chorioallantoic membranes.
CONCLUSION
Celastrol, which can inhibit angiogenesis, could be developed as an antiangiogenic drug.
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