Sakagami H, Takeda M, Kawazoe Y, Nagata K, Ishihama A, Ueda M, Yamazaki S
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
In Vivo. 1992 Sep-Oct;6(5):491-5.
When mice were inoculated intranasally or intracerebrally with lethal doses of influenza virus A/WSN/33, most died within 12 days. However, the infectivity of virus that had been preincubated with a lignin prepared from cones of Pinus parviflora Sieb. et Zucc. (PC-Fr. VI) was significantly reduced. Intraperitoneal or oral administration of PC-Fr. VI, prior to virus inoculation, slightly increased the survival ratio of the infected mice. Experiments using radiolabeled PC-Fr. VI revealed that this fraction effectively binds to virions as well as to cultured cells. These data suggest that PC-Fr. VI either inactivates the virus or induces the anti-viral state in cells by binding to virions or cells.
