Costa-Bauzá Antonia, Barceló Catalina, Perelló Juan, Grases Felix
Laboratory of Renal Lithiasis Research, Faculty of Sciences, University of Illes Balears 07071, Palma de Mallorca, Spain.
Int Urol Nephrol. 2002;34(4):447-51. doi: 10.1023/a:1025671019653.
The aim of this paper is to study possible synergic effects between crystallization-inhibitor molecules of low molecular weight on the hydroxyapatite and brushite crystal nucleation. Kinetic-turbidimetric measurements were performed to follow the nucleation process in synthetic urine at 37 degrees C. Only pyrophosphate + phytate mixture manifested synergic effects on the brushite nucleation, whereas the mixture pyrophosphate + citrate exhibited synergic effects only on the hydroxyapatite nucleation. It seems clear that synergic effects between the crystallization inhibitory capacity of some substances in urine can take place and as a consequence, the high crystallization inhibitory capacity of healthy urine could be assigned not only to the individual inhibitory capacity of each product but also to the synergic effects between different products.
本文旨在研究低分子量结晶抑制剂分子对羟基磷灰石和透钙磷石晶体成核的可能协同作用。进行动力学比浊法测量以跟踪37℃下合成尿液中的成核过程。只有焦磷酸盐+肌醇六磷酸混合物对透钙磷石成核表现出协同作用，而焦磷酸盐+柠檬酸盐混合物仅对羟基磷灰石成核表现出协同作用。显然，尿液中某些物质的结晶抑制能力之间可能会发生协同作用，因此，健康尿液的高结晶抑制能力不仅可以归因于每种产物的个体抑制能力，还可以归因于不同产物之间的协同作用。
