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尿液、焦磷酸盐、柠檬酸盐、镁及糖胺聚糖对草酸钙晶体体外生长和聚集的影响。

The effect of urine, pyrophosphate, citrate, magnesium and glycosaminoglycans on the growth and aggregation of calcium oxalate crystals in vitro.

作者信息

Ryall R L, Harnett R M, Marshall V R

出版信息

Clin Chim Acta. 1981 May;112(3):349-56. doi: 10.1016/0009-8981(81)90458-7.

DOI:10.1016/0009-8981(81)90458-7
PMID:6263523
Abstract

The effects of pyrophosphate, citrate, magnesium, heparin and chondroitin sulphate on the growth and aggregation of calcium oxalate crystals were measured at concentrations likely to be found in 1% urine. The degrees of inhibition of growth and of aggregation caused by these compounds were related to the effects of normal 1% urine on these processes. It was concluded that chondroitin sulphate is responsible for the major portion of the inhibitory effect of urine on crystal aggregation, but that the effect on crystal growth is probably due to the additive or synergistic effects of a number of urinary constituents.

摘要

在可能存在于1%尿液中的浓度下,测定了焦磷酸盐、柠檬酸盐、镁、肝素和硫酸软骨素对草酸钙晶体生长和聚集的影响。这些化合物对生长和聚集的抑制程度与正常1%尿液对这些过程的影响有关。得出的结论是,硫酸软骨素是尿液对晶体聚集抑制作用的主要原因,但对晶体生长的影响可能是由于多种尿液成分的相加或协同作用。

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