Kang Li-Ping, Liu Zhi-Jun, Zhang Lei, Tan Da-Wei, Zhao Yang, Zhao Yu, Chen He-Bing, Ma Bai-Ping
Beijing Institute of Radiation Medicine, Beijing 100850, People's Republic of China.
Magn Reson Chem. 2007 Sep;45(9):725-33. doi: 10.1002/mrc.2037.
An analysis of the polar extracts from Allium ascalonicum L. led to the isolation of two new furostanol saponins (compound 1 and 2) and two known furostanol saponins (compound 3 and 4). On the basis of 1D and 2D NMR (including (1)H, (13)C NMR, (1)H--(1)H COSY, HSQC, TOCSY, HMBC, and NOESY), FAB-MS spectrometry, and chemical methods, their structures were elucidated as (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5alpha-furost-2-one-3beta, 5, 6beta, 26-tetraol-3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (ascalonicoside C, 1), (25R)-26-O-beta-D-glucopyranosyl-22-methoxy-5alpha-furost-2-one-3beta, 5, 6beta, 26-tetraol- 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (ascalonicoside D, 2), (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5-ene-furostan-3beta, 26-diol-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (dichotomin, 3), and (25R)-26-O-beta-D-glucopyranosyl-22-hydroxy-5-ene-furostan-3beta, 26-diol-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-arabinofuranosyl-(1-->4)]-beta-D- glucopyranoside (parisaponin I, 4).
对葱属植物（Allium ascalonicum L.）的极性提取物进行分析后，分离出两种新的呋甾烷醇皂苷（化合物1和2）以及两种已知的呋甾烷醇皂苷（化合物3和4）。基于一维和二维核磁共振（包括¹H、¹³C NMR、¹H–¹H COSY、HSQC、TOCSY、HMBC和NOESY）、快原子轰击质谱（FAB-MS）以及化学方法，确定它们的结构分别为(25R)-26-O-β-D-吡喃葡萄糖基-22-羟基-5α-呋甾-2-酮-3β,5,6β,26-四醇-3-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷（葱属皂苷C，1）、(25R)-26-O-β-D-吡喃葡萄糖基-22-甲氧基-5α-呋甾-2-酮-3β,5,6β,26-四醇-3-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷（葱属皂苷D，2）、(25R)-26-O-β-D-吡喃葡萄糖基-22-羟基-5-烯-呋甾烷-3β,26-二醇-3-O-α-L-吡喃鼠李糖基-(1→4)-α-L-吡喃鼠李糖基-(1→4)-[α-L-吡喃鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷（重楼皂苷，3）和(25R)-26-O-β-D-吡喃葡萄糖基-22-羟基-5-烯-呋甾烷-3β,26-二醇-3-O-α-L-吡喃鼠李糖基-(1→2)-[α-L-阿拉伯呋喃糖基-(1→4)]-β-D-吡喃葡萄糖苷（偏诺皂苷I，4）。
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