舒必利治疗亨廷顿舞蹈病和迟发性运动障碍的双盲试验。
A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia.
作者信息
Quinn N, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):844-7. doi: 10.1136/jnnp.47.8.844.
Abstract
Eleven patients with Huntington's disease and nine patients with tardive dyskinesia participated in a randomised double-blind crossover trial of sulpiride (as sole antidopaminergic therapy) versus placebo. Although functional improvement was not seen in Huntington's disease patients, sulpiride reduced movement count and total dyskinesia score in both conditions. Sulpiride differs pharmacologically in several respects from conventional neuroleptics, and has not been convincingly shown to cause tardive dyskinesia. Among currently available treatments, it may therefore be considered a drug of choice for treatment of tardive dyskinesia.
摘要
11名亨廷顿舞蹈症患者和9名迟发性运动障碍患者参与了一项关于舒必利（作为唯一的抗多巴胺能疗法）与安慰剂的随机双盲交叉试验。虽然在亨廷顿舞蹈症患者中未观察到功能改善，但在这两种情况下舒必利均降低了运动计数和总的运动障碍评分。舒必利在药理学上在几个方面与传统抗精神病药物不同，并且尚未被确凿证明会导致迟发性运动障碍。因此，在目前可用的治疗方法中，它可能被认为是治疗迟发性运动障碍的首选药物。
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