离散基因位点调节中枢神经系统中的神经退行性变、淋巴细胞浸润和主要组织相容性复合体II类表达。
Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS.
作者信息
Lidman Olle, Swanberg Maria, Horvath Linn, Broman Karl W, Olsson Tomas, Piehl Fredrik
机构信息
Department of Clinical Neuroscience, Karolinska Institute, Karolinska Hospital, S-17176, Stockholm, Sweden.
出版信息
J Neurosci. 2003 Oct 29;23(30):9817-23. doi: 10.1523/JNEUROSCI.23-30-09817.2003.
Abstract
Neurodegeneration and inflammation are fundamental aspects of many neurological diseases. A genome-wide scan of the response to ventral root avulsion (VRA) in a rat F2 cross discloses specific gene regions that regulate these processes. Two gene loci displayed linkage to neurodegeneration and T cell infiltration, respectively, and a single locus displayed extreme linkage to VRA-induced major histocompatibility complex class II expression on microglia. The demonstration that polymorphic genes in different loci control neurodegeneration and CNS inflammation has implications for various experimental rodent nervous system paradigms and potentially for genetically regulated susceptibility to a variety of human CNS diseases.
摘要
神经退行性变和炎症是许多神经疾病的基本特征。对大鼠F2杂交后代腹根撕脱（VRA）反应进行全基因组扫描，发现了调控这些过程的特定基因区域。两个基因位点分别与神经退行性变和T细胞浸润相关联，一个位点与VRA诱导的小胶质细胞上主要组织相容性复合体II类表达存在极端关联。不同位点的多态性基因控制神经退行性变和中枢神经系统炎症这一发现，对各种实验性啮齿动物神经系统模型具有启示意义，并且可能对多种人类中枢神经系统疾病的遗传易感性也有启示作用。
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