半胱天冬酶激活。
Caspase activation.
作者信息
Boatright Kelly M, Salvesen Guy S
机构信息
Program in Apoptosis and Cell Death, Burnham Institute, Department of Molecular Pathology, University of California, San Diego, La Jolla, CA 92037, USA.
出版信息
Biochem Soc Symp. 2003(70):233-42. doi: 10.1042/bss0700233.
Caspase activation is the 'point of no return' commitment to cell death. Synthesized as inactive zymogens, it is essential that the caspases remain inactive until the death signal is received. It is known for the downstream executioner caspases-3 and -7 that the activation event is proteolytic cleavage, and this had been assumed to apply to the initiator caspases as well. However, recent studies conducted on caspases-2, -8 and -9 have challenged this tenet of caspase activation. In this review we focus on the molecular details of caspase activation, with emphasis on recent work that provides a pleasing explanation for the differential requirements for the activation of executioner and initiator caspases.
半胱天冬酶激活是细胞死亡的“不可逆点”。半胱天冬酶以无活性的酶原形式合成，在接收到死亡信号之前保持无活性至关重要。已知下游执行性半胱天冬酶-3和-7的激活事件是蛋白水解切割，并且此前一直认为这也适用于起始半胱天冬酶。然而，最近针对半胱天冬酶-2、-8和-9开展的研究对这一半胱天冬酶激活原则提出了挑战。在本综述中，我们聚焦于半胱天冬酶激活的分子细节，重点关注近期的研究工作，这些工作为执行性和起始性半胱天冬酶激活的不同要求提供了令人满意的解释。
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