• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The role of pharmacokinetics in the development of biotechnologically derived agents.

作者信息

Wills R J, Ferraiolo B L

机构信息

Department of Drug Metabolism, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey.

出版信息

Clin Pharmacokinet. 1992 Dec;23(6):406-14. doi: 10.2165/00003088-199223060-00002.

DOI:10.2165/00003088-199223060-00002
PMID:1458760
Abstract
摘要

相似文献

1
The role of pharmacokinetics in the development of biotechnologically derived agents.
Clin Pharmacokinet. 1992 Dec;23(6):406-14. doi: 10.2165/00003088-199223060-00002.
2
Pharmacokinetics of biotech drugs: peptides, proteins and monoclonal antibodies.生物技术药物的药代动力学：肽、蛋白质和单克隆抗体。
Curr Drug Metab. 2009 Sep;10(7):661-91. doi: 10.2174/138920009789895499.
3
Transdermal iontophoresis. Pharmacokinetic considerations.
Clin Pharmacokinet. 1994 May;26(5):327-34. doi: 10.2165/00003088-199426050-00001.
4
The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals.用于蛋白质和肽类生物药物的位点特异性给药系统的研发。
Trends Biotechnol. 1998 Aug;16(8):343-9. doi: 10.1016/s0167-7799(98)01186-x.
5
Prodrugs of peptides and proteins for improved formulation and delivery.用于改善制剂和递送的肽和蛋白质前药。
Annu Rev Pharmacol Toxicol. 1993;33:521-44. doi: 10.1146/annurev.pa.33.040193.002513.
6
Carrier-based strategies for targeting protein and peptide drugs to the lungs.将蛋白质和肽类药物靶向输送至肺部的基于载体的策略。
AAPS J. 2005 Mar 24;7(1):E20-41. doi: 10.1208/aapsj070104.
7
Rational design of agents to transiently increase paracellular permeability.用于短暂增加细胞旁通透性的药物的合理设计。
J Control Release. 2015 Jul 28;210:246. doi: 10.1016/j.jconrel.2015.06.003.
8
Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine.呼吸道对肽和蛋白质的吸收以及局部给药疫苗的开发潜力。
Crit Rev Ther Drug Carrier Syst. 1990;7(1):35-97.
9
Enzymatic barriers to peptide and protein absorption.肽和蛋白质吸收的酶屏障
Crit Rev Ther Drug Carrier Syst. 1988;5(2):69-97.
10
Some approaches to improve bioavailability of peptides and proteins through oral and other mucosal routes.一些通过口服和其他黏膜途径提高肽和蛋白质生物利用度的方法。
Pharmazie. 1997 May;52(5):339-45.

引用本文的文献

1
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses.高度聚集的抗体疗法可以增强体外固有和晚期 T 细胞免疫反应。
J Biol Chem. 2012 Jul 20;287(30):25266-79. doi: 10.1074/jbc.M111.330902. Epub 2012 May 14.
2
Specificity and accuracy data for ligand-binding assays for macromolecules should be interpreted with caution.大分子配体结合分析的特异性和准确性数据应谨慎解读。
AAPS J. 2008 Sep;10(3):433-4. doi: 10.1208/s12248-008-9047-2. Epub 2008 Jul 17.
3
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice.

本文引用的文献

1
Quantitative Relations in the Physiological Constitutions of Mammals.哺乳动物生理构成中的数量关系。
Science. 1949 Jun 10;109(2841):579-85. doi: 10.1126/science.109.2841.579.
2
A comparison of mass balance, pharmacokinetics and disposition of [14C(U)]- and [125I]recombinant human interleukin-2 in cynomolgus monkeys.食蟹猴体内[14C(U)]-和[125I]重组人白细胞介素-2的质量平衡、药代动力学及处置比较
Drug Metab Dispos. 1995 Sep;23(9):904-9.
3
Renal tubular processing of small peptide hormones.小肽类激素的肾小管处理
聚集对重组人凝血因子VIII在甲型血友病小鼠体内免疫原性的影响。
J Pharm Sci. 2006 Feb;95(2):358-71. doi: 10.1002/jps.20529.
4
Pegylation: a novel process for modifying pharmacokinetics.聚乙二醇化：一种改善药代动力学的新方法。
Clin Pharmacokinet. 2001;40(7):539-51. doi: 10.2165/00003088-200140070-00005.
5
Effects of route and formulation on clinical pharmacokinetics of interleukin-2.给药途径和剂型对白介素-2临床药代动力学的影响。
Clin Pharmacokinet. 1994 Jul;27(1):19-31. doi: 10.2165/00003088-199427010-00003.
J Lab Clin Med. 1982 Jul;100(1):1-14.
4
Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection.
Clin Pharmacol Ther. 1984 May;35(5):722-7. doi: 10.1038/clpt.1984.101.
5
Effect of desialylation of human chorionic gonadotropin on its metabolic clearance rate in humans.人绒毛膜促性腺激素去唾液酸化对其在人体内代谢清除率的影响。
J Clin Endocrinol Metab. 1984 Dec;59(6):1215-9. doi: 10.1210/jcem-59-6-1215.
6
Proteins in bile: how they get there and what they do.胆汁中的蛋白质：它们如何到达那里以及发挥何种作用。
Am J Physiol. 1984 Sep;247(3 Pt 1):G199-205. doi: 10.1152/ajpgi.1984.247.3.G199.
7
Insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man.健康男性持续输注和推注常规猪胰岛素及人胰岛素后的胰岛素药代动力学
Metabolism. 1983 May;32(5):478-86. doi: 10.1016/0026-0495(83)90010-0.
8
Bioassays in modern peptide research.现代肽研究中的生物测定法。
Peptides. 1982 May-Jun;3(3):223-30. doi: 10.1016/0196-9781(82)90082-1.
9
The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.神经肽的代谢。肽的水解，包括脑啡肽、速激肽及其类似物，由内肽酶-24.11进行。
Biochem J. 1984 Oct 15;223(2):433-40. doi: 10.1042/bj2230433.
10
Effects of three recombinant human leukocyte interferons on drug metabolism in mice.三种重组人白细胞干扰素对小鼠药物代谢的影响。
Drug Metab Dispos. 1982 Nov-Dec;10(6):579-85.