LaRusso N F
Am J Physiol. 1984 Sep;247(3 Pt 1):G199-205. doi: 10.1152/ajpgi.1984.247.3.G199.
Experimental hepatologists have recently directed increasing attention to biliary proteins. Studies have been performed to clarify which proteins are in bile, how they get there, and what they do. Results derived with a variety of analytical techniques and several experimental models indicate that there are many individual proteins in bile; some get there from plasma across hepatocytes via specific transport processes involving vesicles, while others are derived directly from cells in the liver. It appears that some proteins are released into bile after hepatocyte degradation while others may have important and specific functions. Quantitative or qualitative abnormalities of certain biliary proteins could be important in the pathophysiology of selected diseases.
实验性肝病学家最近越来越关注胆汁蛋白。已经开展了多项研究来阐明哪些蛋白质存在于胆汁中、它们如何到达那里以及它们发挥什么作用。使用各种分析技术和几种实验模型得出的结果表明，胆汁中存在许多个体蛋白；一些蛋白通过涉及囊泡的特定转运过程从血浆穿过肝细胞到达那里，而其他蛋白则直接来自肝脏中的细胞。似乎一些蛋白在肝细胞降解后释放到胆汁中，而其他蛋白可能具有重要的特定功能。某些胆汁蛋白的定量或定性异常在特定疾病的病理生理学中可能很重要。
