拓展用于DNA/RNA杂交选择性的吡咯烷基PNA类似物库：氨乙基吡咯烷酮PNA（aepone-PNA）。
Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA).
作者信息
Sharma Nagendra K, Ganesh Krishna N
机构信息
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
出版信息
Chem Commun (Camb). 2003 Oct 7(19):2484-5. doi: 10.1039/b307362a.
DOI:10.1039/b307362a
PMID:14587743
Abstract
New PNA analogues derived from aminoethylpyrrolidin-5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified PNA.
摘要
源自氨基乙基吡咯烷-5-酮主链的新型肽核酸类似物与未修饰的肽核酸相比，显示出aepone-肽核酸:DNA杂交体的稳定性以及相应RNA杂交体的不稳定性。
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