顺式环戊基肽核酸（cpPNA）作为受限手性肽核酸类似物：DNA/RNA杂交的立体化学依赖性
cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization.
作者信息
Govindaraju T, Kumar Vaijayanti A, Ganesh Krishna N
机构信息
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India.
出版信息
Chem Commun (Camb). 2004 Apr 7(7):860-1. doi: 10.1039/b317000d. Epub 2004 Mar 2.
DOI:10.1039/b317000d
PMID:15045100
Abstract
DNA/RNA hybridization studies of PNA-T oligomers with cis-(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.
摘要
对主链中含有顺式-(1S,2R/1R,2S)-环戊基单元的肽核酸-T寡聚物进行的DNA/RNA杂交研究表明，其结合具有立体化学依赖性，且能区分RNA/DNA。
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