Takano Hiroyuki, Zou Yunzeng, Hasegawa Hiroshi, Akazawa Hiroshi, Nagai Toshio, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Antioxid Redox Signal. 2003 Dec;5(6):789-94. doi: 10.1089/152308603770380098.
Reactive oxygen species (ROS) are proposed to contribute to the deterioration of cardiac function in patients with heart diseases. It has been reported that ROS are increased in the failing heart and involved in atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure. Antioxidant enzymes are decreased in the decompensated heart, depressing defense mechanisms against oxidative stress. A variety of proteins, including receptors, ionic channels, transporters, and components of signal transduction pathways, are substrates of oxidation by ROS. ROS also function as signal transduction intermediates to induce transcription factor activation, gene expression, cell growth, and apoptosis. Recently, the upstream and downstream molecules of ROS in signal transduction pathways have been the subjects of intense investigation. These molecules include the mitogen-activated protein kinase family, the Rho family of small GTP binding proteins, the Src family of tyrosine kinases, Ras, and cytokines. The modulation of oxidative stress-induced signaling pathways is effective for preventing the progression of heart diseases.
活性氧（ROS）被认为会导致心脏病患者的心功能恶化。据报道，在衰竭心脏中ROS水平升高，且参与动脉粥样硬化、心肌缺血/再灌注损伤及心力衰竭。在失代偿心脏中抗氧化酶减少，削弱了对抗氧化应激的防御机制。多种蛋白质，包括受体、离子通道、转运体及信号转导通路的组成成分，都是ROS氧化的底物。ROS还作为信号转导中间体发挥作用，诱导转录因子激活、基因表达、细胞生长及凋亡。近来，信号转导通路中ROS的上下游分子一直是深入研究的对象。这些分子包括丝裂原活化蛋白激酶家族、小GTP结合蛋白的Rho家族、酪氨酸激酶的Src家族、Ras及细胞因子。调节氧化应激诱导的信号通路对预防心脏病进展有效。
