Gorący Iwona, Rębacz-Maron Ewa, Korbecki Jan, Gorący Jarosław
Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
Institute of Biology, Department of Ecology and Anthropology, University of Szczecin, Szczecin, Poland.
PeerJ. 2021 Nov 1;9:e12207. doi: 10.7717/peerj.12207. eCollection 2021.
The study investigated the relationship between the concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in the blood serum of patients with heart failure (HF) and the potential influence on the development and progression of HF.
MATERIAL & METHODS: The study included 214 patients (155 men and 59 women), aged 40-87 years, presenting symptoms or signs typical of HF (according to the NYHA functional classification). Serum concentrations were determined for Mg, Ca, Fe, Cu, Zn, P, C-reactive protein (CRP), creatinine, urea, triglyceride levels (TG), total cholesterol (CH), high density protein (HDL), low density protein (LDL). The levels of macro-and microminerals were analysed using inductively coupled serum optical emission spectrometry (ICP-OES).
Our study confirmed the role of known risk factors in the development of heart failure, including: overweight, diabetes, hypertension, high triglycerides (TG), high total cholesterol (CH), high levels of low density protein (LDL) and reduced levels of high density protein (HDL), high CRP, high creatinine. Moreover, deficient serum concentrations of Mg (47% of the studied men and 54% of the women) and Cu (in 44% of men and more than 30% of women) were observed, as well as subnormal serum Fe (2% of women) and Zn (1% of men). Elevated serum Ca was found in 50% of men and 49% of women. In 44% of the studied men and 52% of the studied women, levels in serum were also above-average. The study revealed a significant positive correlation between serum levels of Ca and Mg, and also Ca and Cu in women. In men, serum Cu was positively correlated with Mg and Ca concentrations. In patients from group 1 (NYHA I-II), Mg content was positively correlated with Ca and Cu. In this patient group, Ca was also positively associated with Cu content in serum. In group 2 (NYHA III-IV), serum Mg concentration was significantly positively correlated with that of Cu and Ca.
Changes in the serum concentrations of macro-and microminerals may significantly affect the severity of HF in Polish patients.
本研究调查了心力衰竭（HF）患者血清中镁、钙、铁、铜、锌、磷的浓度与人体测量学及生化指标之间的关系，以及这些元素对心力衰竭发生发展的潜在影响。
本研究纳入了214例年龄在40 - 87岁之间、有典型心力衰竭症状或体征（根据纽约心脏病协会功能分级）的患者（155名男性和59名女性）。测定血清中镁、钙、铁、铜、锌、磷、C反应蛋白（CRP）、肌酐、尿素、甘油三酯水平（TG）、总胆固醇（CH）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）的浓度。采用电感耦合血清光发射光谱法（ICP - OES）分析常量和微量元素水平。
我们的研究证实了已知危险因素在心力衰竭发生中的作用，包括：超重、糖尿病、高血压、高甘油三酯（TG）、高总胆固醇（CH）、低密度脂蛋白（LDL）水平升高和高密度脂蛋白（HDL）水平降低、高CRP、高肌酐。此外，观察到血清镁浓度不足（47%的男性和54%的女性）和铜浓度不足（44%的男性和超过30%的女性），以及血清铁（2%的女性）和锌（1%的男性）低于正常水平。50%的男性和49%的女性血清钙升高。在44%的男性和52%的女性研究对象中，血清磷水平也高于平均水平。研究发现，女性血清钙与镁以及钙与铜之间存在显著正相关。在男性中，血清铜与镁和钙浓度呈正相关。在1组（纽约心脏病协会I - II级）患者中，镁含量与钙和铜呈正相关。在该患者组中，血清钙也与铜含量呈正相关。在2组（纽约心脏病协会III - IV级）中，血清镁浓度与铜和钙浓度显著正相关。
波兰患者血清中常量和微量元素浓度的变化可能显著影响心力衰竭的严重程度。
