Bergui M, Bradac G B, Oguz K K, Boghi A, Geda C, Gatti G, Schiffer D
Department of Neuroradiology, University of Turin, Via Cherasco 15, 10126, Torino, Italy.
Neuroradiology. 2004 Jan;46(1):22-5. doi: 10.1007/s00234-003-1115-9. Epub 2003 Oct 31.
We examined MRI of two patients with progressive multifocal leukoencephalopathy (PML), including diffusion-weighted imaging (DWI), with calculation of apparent diffusion coefficients (ADC). The pathology findings of one patient were compared with those of MRI. The lesions had different ADC and DWI appearances, depending on the stage of the disease. Newer lesions and the advancing edge of large lesions had normal-to-low ADC and gave high signal on DWI. Older lesions and the centre of large lesions had increased ADC and gave low signal. High signal on DWI and low ADC mark the regions of active infection and cell swelling, distinguishing them from areas of reparative gliosis.
我们对两名进行性多灶性白质脑病（PML）患者进行了磁共振成像（MRI）检查，包括扩散加权成像（DWI），并计算了表观扩散系数（ADC）。将其中一名患者的病理结果与MRI结果进行了比较。根据疾病阶段，病变在ADC和DWI上有不同表现。较新的病变以及大病变的进展边缘ADC值正常至偏低，在DWI上呈高信号。较旧的病变以及大病变的中心ADC值升高，在DWI上呈低信号。DWI上的高信号和低ADC值标志着活跃感染和细胞肿胀区域，将它们与修复性胶质增生区域区分开来。
