螯合剂在小鼠实验性铀中毒中的作用：随结构及给药时间的变化

The action of chelating agents in experimental uranium intoxication in mice: variations with structure and time of administration.

作者信息

Domingo J L, Colomina M T, Llobet J M, Jones M M, Singh P K, Campbell R A

机构信息

Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Spain.

出版信息

Fundam Appl Toxicol. 1992 Oct;19(3):350-7. doi: 10.1016/0272-0590(92)90173-f.

DOI:10.1016/0272-0590(92)90173-f

PMID:1459366

Abstract

The determination of the relative abilities of 11 chelating agents to enhance the urinary and fecal excretion of uranium when administered 10 min after uranyl acetate dihydrate (UAD) in mice showed that the most effective of these were Tiron, desferrioxamine, and 1,2-dimethyl-3-hydroxypyrid-4-one. An increase in the interval between UAD administration and that of the chelating agent drastically reduces the net mobilization of the uranium by the chelating agents examined. When given shortly after UAD, Tiron produced the greatest reduction in renal and bone levels of uranium. None of the chelating agents were able to affect the bone levels of uranium when administered 24 hr or more after the administration of the UAD.

摘要

在给小鼠腹腔注射二水合醋酸双氧铀（UAD）10分钟后，测定11种螯合剂促进铀经尿液和粪便排泄的相对能力，结果表明其中最有效的是钛铁试剂、去铁胺和1,2 - 二甲基 - 3 - 羟基吡啶 - 4 - 酮。UAD给药与螯合剂给药之间的时间间隔增加，会大幅降低所检测螯合剂对铀的净动员作用。在UAD给药后不久给予钛铁试剂，可使肾脏和骨骼中的铀含量降低最多。在UAD给药24小时或更长时间后给予螯合剂，没有一种能影响骨骼中的铀含量。