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链脲佐菌素对培养的早期大鼠胚胎的影响。

Effects of streptozotocin on early rat embryos grown in culture.

作者信息

Deuchar E M

出版信息

Experientia. 1978 Jan 15;34(1):84-5. doi: 10.1007/BF01921917.

DOI:10.1007/BF01921917
PMID:145950
Abstract

Addition of 1 mg/ml streptozotocin to serum in which 10-day rat embryos are cultured reduces their growth and viability. There is therefore a risk that administration of this drug to pregnant animals to induce diabetes could also have direct, deleterious effects on the embryos.

摘要

向培养10天大的大鼠胚胎的血清中添加1毫克/毫升链脲佐菌素会降低胚胎的生长速度和存活率。因此,给怀孕动物施用这种药物来诱发糖尿病,可能也会对胚胎产生直接的有害影响。

相似文献

1
Effects of streptozotocin on early rat embryos grown in culture.链脲佐菌素对培养的早期大鼠胚胎的影响。
Experientia. 1978 Jan 15;34(1):84-5. doi: 10.1007/BF01921917.
2
Preimplantation embryo development in ICR mice after streptozotocin treatment.
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Abnormalities induced in cultured rat embryos by hyperglycaemia.高血糖对培养的大鼠胚胎造成的异常。
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Teratogenic effects of excess glucose on head-fold rat embryos in culture.体外培养中过量葡萄糖对大鼠头部折叠期胚胎的致畸作用。
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Development of rat embryos in culture media containing different concentrations of normal and diabetic rat serum.在含有不同浓度正常和糖尿病大鼠血清的培养基中大鼠胚胎的发育情况。
Teratology. 1992 Nov;46(5):473-83. doi: 10.1002/tera.1420460512.
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Growth of 9.5-day rat embryos in human serum.
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Effects of nitrous oxide on day 9 rat embryos grown in culture.氧化亚氮对体外培养的9日龄大鼠胚胎的影响。
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In vitro development of rat embryos obtained from diabetic mothers.从糖尿病母亲获得的大鼠胚胎的体外发育
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A stage-dependent effect of ethanol on 9.5-day rat embryos grown in culture and the role played by the concomitant rise in osmolality.乙醇对体外培养的9.5天大的大鼠胚胎的阶段依赖性影响以及伴随的渗透压升高所起的作用。
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引用本文的文献

1
Fetal diabetes in rats and its effect on placental glycogen.大鼠的胎儿糖尿病及其对胎盘糖原的影响。
Diabetologia. 1985 Apr;28(4):244-9. doi: 10.1007/BF00282241.
2
Diabetes in pregnancy 1985.
Diabetologia. 1986 Jan;29(1):1-9. doi: 10.1007/BF02427272.

本文引用的文献

1
Development of rat embryos cultured in blood sera.在血清中培养的大鼠胚胎的发育
J Reprod Fertil. 1966 Dec;12(3):509-24. doi: 10.1530/jrf.0.0120509.
2
Streptozotocin diabetes in pregnant and nonpregnant rats.妊娠和非妊娠大鼠的链脲佐菌素糖尿病
Metabolism. 1970 Dec;19(12):1014-9. doi: 10.1016/0026-0495(70)90024-7.
3
[Behavior of rats with chronic streptozotocin diabetes].[慢性链脲佐菌素糖尿病大鼠的行为]
Klin Wochenschr. 1969 Oct 15;47(20):1120-1. doi: 10.1007/BF01496654.
4
Use of streptozotocin as diabetic agent in pregnant rats.链脲佐菌素在孕鼠中作为糖尿病诱导剂的应用。
Endocrinology. 1971 Dec;89(6):1537-40. doi: 10.1210/endo-89-6-1537.
5
The mechanism of axial rotation in the rat embryo: an experimental study in vitro.大鼠胚胎轴向旋转的机制:一项体外实验研究。
J Embryol Exp Morphol. 1971 Apr;25(2):189-201.
6
Drugs producing diabetes through damage of the insulin secreting cells.通过损伤胰岛素分泌细胞而导致糖尿病的药物。
Pharmacol Rev. 1970 Dec;22(4):485-518.
7
Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations.母体糖尿病导致的大鼠胚胎畸形:初步观察
J Embryol Exp Morphol. 1977 Oct;41:93-9.
8
Streptozotocin: its excretion and metabolism in the rat.链脲佐菌素:其在大鼠体内的排泄与代谢
Diabetologia. 1976 Oct;12(5):483-8. doi: 10.1007/BF01219512.