Guido S, Joseph T
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Indian J Exp Biol. 1992 Apr;30(4):292-4.
Different classes of calcium antagonists, viz. verapamil (diphenylalkylamine), diltiazem (benzothiazepine), nifedipine, felodipine and nimodipine (dihydropyridines), were examined for their effects on lipid profile in rats. Clofibrate was the reference standard. Clofibrate significantly prevented the rise of serum triglycerides and total cholesterol produced by high fat diet and raised antiatherogenic index to 1.6 times than that of high fat diet controls. Of the calcium antagonists studied, felodipine was most effective in preventing the rise of serum triglycerides and total cholesterol in high fat diet fed rats. Felodipine's antiatherogenic index was very high (886%)--much more than that of clofibrate (303%). Diltiazem and nimodipine which also significantly prevented the rise in triglycerides and total cholesterol produced by high fat diet had a moderately beneficial antiatherogenic index similar to that of clofibrate. Though verapamil and nifedipine slightly increased the triglyceride levels, total cholesterol levels were reduced only by verapamil and not by nifedipine. Despite this both these drugs moderately raised antiatherogenic index similar to clofibrate.
研究了不同类别的钙拮抗剂，即维拉帕米（二苯基烷基胺）、地尔硫䓬（苯并硫氮杂䓬）、硝苯地平、非洛地平和尼莫地平（二氢吡啶类）对大鼠血脂谱的影响。氯贝丁酯为参考标准。氯贝丁酯显著预防了高脂饮食引起的血清甘油三酯和总胆固醇升高，并使抗动脉粥样硬化指数比高脂饮食对照组提高了1.6倍。在所研究的钙拮抗剂中，非洛地平在预防高脂饮食喂养大鼠的血清甘油三酯和总胆固醇升高方面最有效。非洛地平的抗动脉粥样硬化指数非常高（886%），远高于氯贝丁酯（303%）。地尔硫䓬和尼莫地平也显著预防了高脂饮食引起的甘油三酯和总胆固醇升高，其抗动脉粥样硬化指数具有适度的有益作用，与氯贝丁酯相似。虽然维拉帕米和硝苯地平略微提高了甘油三酯水平，但只有维拉帕米降低了总胆固醇水平，硝苯地平则没有。尽管如此，这两种药物都适度提高了抗动脉粥样硬化指数，与氯贝丁酯相似。
