Hozayen Walaa G, Mahmoud Ayman M, Soliman Hanan A, Mostafa Sanura R
Department of Chemistry, Division of Biochemistry, Faculty of Science, Beni-Suef University, Egypt.
Department of Zoology, Division of Physiology, Faculty of Science, Beni-Suef University, Egypt.
J Intercult Ethnopharmacol. 2016 Jan 5;5(1):57-64. doi: 10.5455/jice.20151230055930. eCollection 2016 Jan-Feb.
The current study aimed to investigate the anti-hyperglycemic, anti-hyperlipidemic and insulin sensitizing effects of the cyanobacterium Spirulina versicolor extract in fructose-fed rats.
Rats were fed 30% fructose solution in drinking water for 4 weeks. Animals exhibited hyperglycemia and hyperinsulinemia were selected for further investigations. Diabetic and control rats were orally supplemented with 50 mg/kg body weight S. versicolor extract for 4 weeks.
At the end of 8 weeks, fructose-fed rats showed a significant increase in serum glucose, insulin, cholesterol, triglycerides, cardiovascular risk indices and insulin resistance. Treatment of the fructose-fed rats with S. versicolor extract improved this metabolic profile. Fructose feeding produced a significant increase in serum tumor necrosis factor alpha and a decrease in adiponectin levels. In addition, fructose-fed rats exhibited a significant increase in liver, kidney and heart lipid peroxidation levels, and declined antioxidant defenses. Supplementation of the fructose-fed rats with S. versicolor extract reversed these alterations.
S. versicolor attenuates hyperglycemia-mediated oxidative stress and inflammation, and is thus effective in improving insulin sensitivity in fructose-fed rats.
本研究旨在探讨蓝藻变色螺旋藻提取物对喂食果糖的大鼠的降血糖、降血脂及胰岛素增敏作用。
给大鼠饮用含30%果糖的溶液，持续4周。选择出现高血糖和高胰岛素血症的动物进行进一步研究。糖尿病大鼠和对照大鼠口服补充50 mg/kg体重的变色螺旋藻提取物，持续4周。
在8周结束时，喂食果糖的大鼠血清葡萄糖、胰岛素、胆固醇、甘油三酯、心血管风险指数和胰岛素抵抗显著增加。用变色螺旋藻提取物治疗喂食果糖的大鼠改善了这种代谢状况。喂食果糖导致血清肿瘤坏死因子α显著增加，脂联素水平降低。此外，喂食果糖的大鼠肝脏、肾脏和心脏的脂质过氧化水平显著增加，抗氧化防御能力下降。给喂食果糖的大鼠补充变色螺旋藻提取物可逆转这些改变。
变色螺旋藻可减轻高血糖介导的氧化应激和炎症，因此对改善喂食果糖的大鼠的胰岛素敏感性有效。
