Asdaq Syed Mohammed Basheeruddin
Krupanidhi College of Pharmacy, Varthur Hobli, Bangalore 560035, India ; Department of Pharmacology, Al-Maarefa College for Science and Technology, P.O. Box 71666, Riyadh 11597, Saudi Arabia.
Evid Based Complement Alternat Med. 2015;2015:328545. doi: 10.1155/2015/328545. Epub 2015 Mar 31.
Aged garlic extract (AGE) is one of the unique preparations standardized with 100% bioavailable active ingredients found in the bloodstream. The current research was aimed at exploring the role of AGE and its chief active constituent, s-allyl cysteine (SAC) as antioxidant and hypolipidemic agent in rats. At the end of treatment of AGE and SAC, separated serum and freshly prepared liver tissue homogenate were analyzed for biochemical enzymes and biomarkers to evaluate and compare potencies of investigational agents. Both AGE and SAC significantly declined elevated levels of triglyceride, total cholesterol, ALP, AST, ALT, malondialdehyde, glutathione peroxidase enzyme activity, total glutathione and oxidised glutathione in serum and inclined superoxide dismutase, catalase, ferric reducing/antioxidant power, and total sulfhydryl values in liver tissue with reduction in thiobarbituric acid reactive species. The protective effects were superior with AGE compared with SAC indicating potential implication of other active constituents apart from SAC in AGE for combating hyperlipidemic stress.
aged garlic extract (AGE) 是一种独特的制剂，其活性成分在血液中具有100%的生物利用度。当前的研究旨在探讨AGE及其主要活性成分S-烯丙基半胱氨酸（SAC）作为大鼠抗氧化剂和降血脂剂的作用。在AGE和SAC治疗结束时，对分离出的血清和新鲜制备的肝组织匀浆进行生化酶和生物标志物分析，以评估和比较受试药物的效力。AGE和SAC均显著降低了血清中甘油三酯、总胆固醇、碱性磷酸酶、天冬氨酸转氨酶、丙氨酸转氨酶、丙二醛、谷胱甘肽过氧化物酶活性、总谷胱甘肽和氧化型谷胱甘肽的升高水平，并提高了肝组织中超氧化物歧化酶、过氧化氢酶、铁还原/抗氧化能力和总巯基值，同时硫代巴比妥酸反应性物质减少。与SAC相比，AGE的保护作用更优，这表明除SAC外，AGE中的其他活性成分在对抗高脂血症应激中可能具有潜在作用。
