Sen P, Maiti P C, Puri S, Ray A, Audulov N A, Valdman A V
Department of Pharmacology, University College of Medical Sciences, Delhi, India.
Indian J Exp Biol. 1992 Jul;30(7):592-6.
Effects of restraint stress (RS) and its modulation by O. sanctum (Os), eugenol and T. malabarica (Tm) were evaluated on some biochemical and biophysical parameters in rats. RS induced elevations in blood glucose and urea levels, were unaffected by either Os, eugenol or Tm pretreatment. However, both Os and eugenol lowered RS-induced cholesterol levels. RS also caused a generalized increase in enzyme activity and Os, eugenol or Tm effectively lowered the RS-induced elevations in lactate dehydrogenase (LDH) and alkaline phosphatase. RS also induced (a) increased membrane protein clusterization, (b) increased membrane fluidity and (c) reduced membrane thickness--in RBC membrane, whereas, the effects on the synaptosomal membrane were less marked. The RS-induced changes in RBC membrane dynamics were attenuated/reversed by Os, eugenol or Tm, in a differential manner. These biochemical and membrane changes during Rs and their modulation by the adaptogens are discussed in light of the possible mechanisms of action of these agents, during such aversive stimuli.
研究了束缚应激（RS）及其被神圣罗勒（Os）、丁香酚和马拉巴罗勒（Tm）调节对大鼠某些生化和生物物理参数的影响。RS导致血糖和尿素水平升高，而Os、丁香酚或Tm预处理对此无影响。然而，Os和丁香酚均降低了RS诱导的胆固醇水平。RS还导致酶活性普遍增加，而Os、丁香酚或Tm有效地降低了RS诱导的乳酸脱氢酶（LDH）和碱性磷酸酶升高。RS还诱导红细胞膜（a）膜蛋白聚集增加、（b）膜流动性增加和（c）膜厚度减小，而对突触体膜的影响则不太明显。Os、丁香酚或Tm以不同方式减弱/逆转了RS诱导的红细胞膜动力学变化。根据这些药物在这种厌恶刺激期间可能的作用机制，讨论了RS期间的这些生化和膜变化及其被适应原调节的情况。
