Pandit M, Pramanik M, Banerjee A
Department of Biophysics, Bose Institute, Calcutta, India.
Indian J Exp Biol. 1996 Jan;34(1):37-40.
A new gamma-aminobutyric acid derivative N-phthloyl GABA (P-GABA) was found to possess anticonvulsant, antiepileptic, antiulcer and antinociceptive activities. Effect of cold restrain stress (CRS) and its modulation by P-GABA were evaluated on some biochemical and biophysical parameters in rats. CRS induced elevations in blood sugar level were unaffected by P-GABA treatment. CRS also caused an increase of Na+K+ ATPase activities, and decrease of lipid peroxidation in RBC membrane. CRS also induced (a) membrane protein clusterization, (b) increased membrane fluidity and (c) reduced thickness. CRS induced RBC membrane dynamics were reversed by P-GABA in a differential manner. However, these parameters in synaptosomal membrane were unaffected by P-GABA.
一种新的γ-氨基丁酸衍生物N-邻苯二甲酰基-GABA（P-GABA）被发现具有抗惊厥、抗癫痫、抗溃疡和抗伤害感受活性。评估了冷束缚应激（CRS）及其被P-GABA调节对大鼠一些生化和生物物理参数的影响。CRS诱导的血糖水平升高不受P-GABA治疗的影响。CRS还导致红细胞膜中Na+K+ ATP酶活性增加，脂质过氧化减少。CRS还诱导（a）膜蛋白聚集、（b）膜流动性增加和（c）厚度减小。CRS诱导的红细胞膜动力学被P-GABA以不同方式逆转。然而，P-GABA对突触体膜中的这些参数没有影响。
