Antistress activity of P-GABA in experimental animals.

A new gamma-aminobutyric acid derivative N-phthloyl GABA (P-GABA) was found to possess anticonvulsant, antiepileptic, antiulcer and antinociceptive activities. Effect of cold restrain stress (CRS) and its modulation by P-GABA were evaluated on some biochemical and biophysical parameters in rats. CRS induced elevations in blood sugar level were unaffected by P-GABA treatment. CRS also caused an increase of Na+K+ ATPase activities, and decrease of lipid peroxidation in RBC membrane. CRS also induced (a) membrane protein clusterization, (b) increased membrane fluidity and (c) reduced thickness. CRS induced RBC membrane dynamics were reversed by P-GABA in a differential manner. However, these parameters in synaptosomal membrane were unaffected by P-GABA.