Miller Morton W, Battaglia Linda F
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, The University of Rochester, Rochester, NY 14642-0001, USA.
Ultrasound Med Biol. 2003 Oct;29(10):1479-85. doi: 10.1016/s0301-5629(03)00966-9.
This paper describes a further test of the hypothesis that cell size is an important physical parameter in ultrasound (US)-induced hemolysis, that is, the larger the cell the greater the potential for sonolysis by a cavitational mechanism. Mouse (M) and human (Hu) erythrocytes in vitro were used; their mean corpuscular volumes were 49.0 and 89.5 fL, respectively. At a US exposure in vitro in the presence of Albunex that yielded an average of 36.8% hemolysis for M blood, the Hu blood yielded an average of 54.0% hemolysis. The data supported the hypothesis. This paper also briefly discusses the difficulty of extrapolating sonolytic in vitro results to those derived in vivo.
