Vaillant L, Monégier du Sorbier C, Arbeille B, de Muret A, Lorette G
Department of Dermatology, University of Tours, France.
Acta Derm Venereol. 1993 Aug;73(4):255-8. doi: 10.2340/0001555573255258.
We describe a new case of signet ring cell peripheral T cell lymphoma in a 45-year-old man. This lymphoma had a very indolent course, since--without treatment--the clinical staging has shown no evidence of disease progression 11 years after initial symptoms. Immunophenotype indicated pan T antigens (Leu 4 CD3, Leu 1 CD5) and T suppressor cytotoxic antigen (IOT8 CD8) expression. Several T antigens (Leu 5b CD2, Leu 9 CD7, Leu 3a CD4) were not expressed. The proliferation index was less than 5% with Ki 67 monoclonal antibodies. The ultrastructural study showed characteristic cytoplasmic vacuoles containing microvesicles. Five cases of signet ring T cell lymphoma, which were very similar to our case, have been previously described. Their characteristics were primary cutaneous presentation, indolent course, good response to current therapies and a long survival period. The indolent course of these signet ring cell lymphomas may indicate that this type of lymphoma is a low grade malignant lymphoma and not only a morphological pattern.
我们报告了一例45岁男性的印戒细胞外周T细胞淋巴瘤新病例。该淋巴瘤病程非常惰性，因为在未接受治疗的情况下，自初次出现症状11年后的临床分期显示无疾病进展迹象。免疫表型显示泛T抗原（Leu 4 CD3、Leu 1 CD5）和T抑制细胞毒性抗原（IOT8 CD8）表达。几种T抗原（Leu 5b CD2、Leu 9 CD7、Leu 3a CD4）未表达。用Ki 67单克隆抗体检测增殖指数小于5%。超微结构研究显示特征性的含有微泡的细胞质空泡。先前已描述过5例与我们病例非常相似的印戒T细胞淋巴瘤。它们的特征为原发性皮肤表现、惰性病程、对当前治疗反应良好且生存期长。这些印戒细胞淋巴瘤的惰性病程可能表明这种类型的淋巴瘤是一种低级别恶性淋巴瘤，而不仅仅是一种形态学模式。
