Marini A, Negretti F, Boehm G, Li Destri M, Clerici-Bagozzi D, Mosca F, Agosti M
Department of Paediatrics and Neonatology, University of Milan, Italy.
Acta Paediatr Suppl. 2003 Sep;91(441):80-1. doi: 10.1111/j.1651-2227.2003.tb00651.x.
Prolonged administration of probiotic in preterm babies induce a rise of specific IgA and IgM antibodies against probiotic. This fact explains why presence of living germs in stools almost disappeared in spite of continuous administration. However some positive influences were observed: decreased ratio of aerobic/anaerobic. Increased ratio of gram +/gram - germs. Prebiotic administration induces after 28 days a significant increase of faecal bifidobacteria and frequency and consistency of stools were more similar to those observed in subjects fed with human milk.
对早产儿长期施用益生菌会导致针对益生菌的特异性 IgA 和 IgM 抗体增加。这一事实解释了为何尽管持续施用益生菌，粪便中活细菌的存在几乎消失。然而，观察到了一些积极影响：需氧菌/厌氧菌比例降低，革兰氏阳性菌/革兰氏阴性菌比例增加。施用益生元 28 天后，粪便双歧杆菌显著增加，粪便的频率和稠度与母乳喂养的受试者更为相似。
